Modulating Treg stability to improve cancer immunotherapy

被引：80

作者：

Kang, Jee Hye ^{[1
,2
]}

Zappasodi, Roberta ^{[1
,2
]}

机构：

[1] Cornell Univ, Weill Cornell Med, Weill Cornell Med Coll, New York, NY 10065 USA

[2] Weill Cornell Grad Sch, Immunol & Microbial Pathogenesis Program, New York, NY 10065 USA

来源：

TRENDS IN CANCER | 2023年 / 9卷 / 11期

关键词：

REGULATORY T-CELLS; TRANSCRIPTION FACTOR; FOXP3; EXPRESSION; DEACETYLASE INHIBITION; RECEPTOR STIMULATION; HISTONE DEACETYLASE; TGF-BETA; TUMOR; PROMOTES; REG;

D O I：

10.1016/j.trecan.2023.07.015

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Immunosuppressive regulatory T cells (Tregs) provide a main mechanism of tumor immune evasion. Targeting Tregs, especially in the tumor microenvironment (TME), continues to be investigated to improve cancer immunotherapy. Re-cent studies have unveiled intratumoral Treg heterogeneity and plasticity, furthering the complexity of the role of Tregs in tumor immunity and immunotherapy response. The phenotypic and functional diversity of intratumoral Tregs can impact their response to therapy and may offer new targets to modulate specific Treg subsets. In this review we provide a unifying framework of critical factors contributing to Treg heterogeneity and plasticity in the TME, and we discuss how this information can guide the development of more specific Tregtargeting therapies for cancer immunotherapy.

引用

收藏

页码：911 / 927

页数：17

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