Modulating Treg stability to improve cancer immunotherapy

被引：53
作者：
Kang, Jee Hye [1 ,2 ]
Zappasodi, Roberta [1 ,2 ]
机构：
[1] Cornell Univ, Weill Cornell Med, Weill Cornell Med Coll, New York, NY 10065 USA
[2] Weill Cornell Grad Sch, Immunol & Microbial Pathogenesis Program, New York, NY 10065 USA
来源：
TRENDS IN CANCER | 2023年 / 9卷 / 11期
关键词：
REGULATORY T-CELLS; TRANSCRIPTION FACTOR; FOXP3; EXPRESSION; DEACETYLASE INHIBITION; RECEPTOR STIMULATION; HISTONE DEACETYLASE; TGF-BETA; TUMOR; PROMOTES; REG;
D O I：
10.1016/j.trecan.2023.07.015
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Immunosuppressive regulatory T cells (Tregs) provide a main mechanism of tumor immune evasion. Targeting Tregs, especially in the tumor microenvironment (TME), continues to be investigated to improve cancer immunotherapy. Re-cent studies have unveiled intratumoral Treg heterogeneity and plasticity, furthering the complexity of the role of Tregs in tumor immunity and immunotherapy response. The phenotypic and functional diversity of intratumoral Tregs can impact their response to therapy and may offer new targets to modulate specific Treg subsets. In this review we provide a unifying framework of critical factors contributing to Treg heterogeneity and plasticity in the TME, and we discuss how this information can guide the development of more specific Tregtargeting therapies for cancer immunotherapy.
引用
收藏
页码：911 / 927
页数：17
相关论文
共 125 条
  • [91] Class I histone deacetylase inhibition is a novel mechanism to target regulatory T cells in immunotherapy
    Shen, Li
    Pili, Roberto
    [J]. ONCOIMMUNOLOGY, 2012, 1 (06): : 948 - 950
  • [92] Class I Histone Deacetylase Inhibitor Entinostat Suppresses Regulatory T Cells and Enhances Immunotherapies in Renal and Prostate Cancer Models
    Shen, Li
    Ciesielski, Michael
    Ramakrishnan, Swathi
    Miles, Kiersten M.
    Ellis, Leigh
    Sotomayor, Paula
    Shrikant, Protul
    Fenstermaker, Robert
    Pili, Roberto
    [J]. PLOS ONE, 2012, 7 (01):
  • [93] Fc-dependent depletion of tumor-infiltrating regulatory T cells co-defines the efficacy of anti-CTLA-4 therapy against melanoma
    Simpson, Tyler R.
    Li, Fubin
    Montalvo-Ortiz, Welby
    Sepulveda, Manuel A.
    Bergerhoff, Katharina
    Arce, Frederick
    Roddie, Claire
    Henry, Jake Y.
    Yagita, Hideo
    Wolchok, Jedd D.
    Peggs, Karl S.
    Ravetch, Jeffrey V.
    Allison, James P.
    Quezada, Sergio A.
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 2013, 210 (09) : 1695 - 1710
  • [94] Concomitant analysis of Helios and Neuropilin-1 as a marker to detect thymic derived regulatory T cells in naive mice
    Singh, Kailash
    Hjort, Marcus
    Thorvaldson, Lina
    Sandler, Stellan
    [J]. SCIENTIFIC REPORTS, 2015, 5
  • [95] Improvement of Foxp3 stability through CNS2 demethylation by TET enzyme induction and activation
    Someya, Kazue
    Nakatsukasa, Hiroko
    Ito, Minako
    Kondo, Taisuke
    Tateda, Kenn-ichi
    Akanuma, Takashi
    Koya, Ikuko
    Sanosaka, Tsukasa
    Kohyama, Jun
    Tsukada, Yu-ichi
    Takamura-Enya, Takeji
    Yoshimura, Akihiko
    [J]. INTERNATIONAL IMMUNOLOGY, 2017, 29 (08) : 365 - 375
  • [96] TGF-β signaling controls Foxp3 methylation and T reg cell differentiation by modulating Uhrf1 activity
    Sun, Xiang
    Cui, Yu
    Feng, Haiyun
    Liu, Haifeng
    Liu, Xiaolong
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 2019, 216 (12) : 2819 - 2837
  • [97] Deacetylase inhibition promotes the generation and function of regulatory T cells
    Tao, Ran
    de Zoeten, Edwin F.
    Oezkaynak, Engin
    Chen, Chunxia
    Wang, Liqing
    Porrett, Paige M.
    Li, Bin
    Turka, Laurence A.
    Olson, Eric N.
    Greene, Mark I.
    Wells, Andrew D.
    Hancock, Wayne W.
    [J]. NATURE MEDICINE, 2007, 13 (11) : 1299 - 1307
  • [98] Immune Monitoring of the Circulation and the Tumor Microenvironment in Patients with Regionally Advanced Melanoma Receiving Neoadjuvant Ipilimumab
    Tarhini, Ahmad A.
    Edington, Howard
    Butterfield, Lisa H.
    Lin, Yan
    Shuai, Yongli
    Tawbi, Hussein
    Sander, Cindy
    Yin, Yan
    Holtzman, Matthew
    Johnson, Jonas
    Rao, Uma N. M.
    Kirkwood, John M.
    [J]. PLOS ONE, 2014, 9 (02):
  • [99] Smad3 and NFAT cooperate to induce Foxp3 expression through its enhancer
    Tone, Yukiko
    Furuuchi, Keiji
    Kojima, Yoshitsugu
    Tykocinski, Mark L.
    Greene, Mark I.
    Tone, Masahide
    [J]. NATURE IMMUNOLOGY, 2008, 9 (02) : 194 - 202
  • [100] Induction of FOXP3 expression in naive human CD4+FOXP3- T cells by T-cell receptor stimulation is transforming growth factor-β-dependent but does not confer a regulatory phenotype
    Tran, Dat Q.
    Ramsey, Heather
    Shevach, Ethan M.
    [J]. BLOOD, 2007, 110 (08) : 2983 - 2990
45678910111213