A randomized, double-blind, placebo-controlled, parallel-group 12-week pilot phase II trial of SaiLuoTong (SLT) for cognitive function in older adults with mild cognitive impairment

被引：2

作者：

Steiner-Lim, Genevieve Z. ^{[1
,2
]}

Bensoussan, Alan ^{[1
]}

Andrews-Marney, Elana R. ^{[1
]}

Al-Dabbas, Mahmoud A. ^{[1
]}

Cave, Adele E. ^{[1
]}

Chiu, Christine L. ^{[3
]}

Christofides, Katerina ^{[1
]}

De Blasio, Frances M. ^{[1
]}

Dewsbury, Lauren S. ^{[1
]}

Fagan, Naomi L. ^{[1
]}

Fogarty, Jack S. ^{[4
]}

Hattom, Lena C. ^{[1
]}

Hohenberg, Mark I.

Jafar, Deyyan ^{[1
,3
]}

Karamacoska, Diana ^{[1
,2
]}

Lim, Chai K. ^{[3
]}

Liu, Jianxun ^{[6
]}

Metri, Najwa-Joelle ^{[1
]}

Oxenham, D. Vincent ^{[7
,8
]}

Ratajec, Holly ^{[1
]}

Roy, Nikita ^{[1
]}

Shipton, Danielle G. ^{[1
]}

Varjabedian, David ^{[1
,5
]}

Chang, Dennis H. ^{[1
]}

机构：

[1] Western Sydney Univ, NICM Hlth Res Inst, Penrith, NSW, Australia

[2] Western Sydney Univ, Translat Hlth Res Inst THRI, Penrith, NSW, Australia

[3] Macquarie Univ, Macquarie Med Sch, Macquarie Pk, NSW, Australia

[4] Nanyang Technol Univ, Natl Inst Educ, Sci Learning Educ Ctr, Singapore, Singapore

[5] Western Sydney Univ, Sch Med, Penrith, NSW, Australia

[6] China Acad Chinese Med Sci, Xiyuan Hosp, Beijing, Peoples R China

[7] Royal North Shore Hosp, Neuropsychol Dept, St Leonards, NSW, Australia

[8] Macquarie Univ, Fac Med Hlth & Human Sci, Sch Psychol Sci, Macquarie Pk, NSW, Australia

来源：

ALZHEIMERS & DEMENTIA-TRANSLATIONAL RESEARCH & CLINICAL INTERVENTIONS | 2023年 / 9卷 / 04期

基金：

澳大利亚国家健康与医学研究理事会; 英国医学研究理事会;

关键词：

Alzheimer's disease; clinical trial; cognitive function; mild cognitive impairment; SaiLuoTong; ALZHEIMERS-DISEASE; GINKGO-BILOBA; RISK-FACTORS; DEMENTIA; PROGRESSION; COMBINATION; EXTRACTS; GINSENG; MEMORY;

D O I：

10.1002/trc2.12420

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

INTRODUCTION: This study primarily aimed to evaluate the efficacy and safety of SaiLuoTong (SLT) on cognition in mild cognitive impairment (MCI).METHODS: Community-dwelling people with MCI aged >= 60 years were randomly assigned to 180 mg/day SLT or placebo for 12 weeks.RESULTS: Thirty-nine participants were randomized to each group (N = 78); 65 were included in the final analysis. After 12 weeks, the between-groups difference in Logical Memory delayed recall scores was 1.40 (95% confidence interval [CI]: 0.22 to 2.58; P = 0.010); Delis-Kaplan Executive Function System Trail Making Test Condition 4 switching and contrast scaled scores were 1.42 (95% CI: -0.15 to 2.99; P = 0.038) and 1.56 (95% CI: -0.09 to 3.20; P = 0.032), respectively; Rey Auditory Verbal Learning Test delayed recall was 1.37 (95% CI: -0.10 to 2.84; P = 0.034); and Functional Activities Questionnaire was 1.21 (95% CI: -0.21 to 2.63; P = 0.047; P < 0.001 after controlling for baseline scores).DISCUSSIONS: LT is well tolerated and may be useful in supporting aspects of memory retrieval and executive function in people with MCI.

引用

页数：11

共 46 条

[1] The diagnosis of mild cognitive impairment due to Alzheimer's disease: Recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease [J].