Morphometric Shape Analysis of Corpus Callosum in Children With Down Syndrome

被引：1

作者：

Gursel, Basak Erdemli ^{[1
]}

Ercan, Ilker ^{[2
]}

Sahin, Ibrahim ^{[3
]}

Ongen, Gokhan ^{[1
]}

机构：

[1] Bursa Uludag Univ, Fac Med, Dept Radiol, TR-16240 Bursa, Turkiye

[2] Bursa Uludag Univ, Fac Med, Dept Biostat, Bursa, Turkiye

[3] Bursa Uludag Univ, Inst Hlth Sci, Dept Biostat, Bursa, Turkiye

来源：

CLINICAL PEDIATRICS | 2024年 / 63卷 / 06期

关键词：

Down syndrome; corpus callosum; splenium; shape analysis; BRAIN; MORPHOLOGY;

D O I：

10.1177/00099228231196933

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Down syndrome (DS) is characterized by varying degrees of mental retardation and delay in neurocognitive functions. Herein, we analyzed the morphometric shape of the corpus callosum (CC) in children with DS. Twenty-three DS cases underwent magnetic resonance imaging and have grossly normal CC, and 23 control group cases were included in this retrospective study (2012-2020). The CC was obtained from T2-weighted mid-sagittal images, and certain anatomical points were marked on the CC. Statistical geometric shapes and deformations of CC were evaluated for both groups. The age range of patients with DS and control group was 6 to 42 months. A statistically significant difference was found in the shape of CC between the groups (P < .001). Deformation was most evident in the splenium in the DS group.

引用

页码：815 / 821

页数：7

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