Impact of platelet endothelial aggregation receptor 1 genotypes and DNA methylation on platelet reactivity in patients with recurrent ischemic stroke treated with clopidogrel

被引：3
作者：
Yang, Jiahui [1 ]
Bao, Zhengjun [1 ]
Hu, Guoyu [2 ]
Luo, Xiaopeng [1 ]
Zhao, Zhen [1 ]
机构：
[1] Cent South Univ, Zhuzhou Hosp, Dept Neurol, Xiangya Med Coll, Zhuzhou, Hunan, Peoples R China
[2] Cent South Univ, Zhuzhou Hosp, Dept Hematol, Xiangya Med Coll, Zhuzhou, Hunan, Peoples R China
来源：
ARCHIVES OF MEDICAL SCIENCE | 2023年 / 19卷 / 02期
关键词：
DNA methylation; ischemic stroke; platelet aggregation; platelet endothelial aggregation receptor 1; ASSOCIATION;
D O I：
10.5114/aoms/159180
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Introduction: The aim of this study is to investigate the role of genetic variation and DNA methylation of PEAR1 rs12041331 in high on-treatment platelet reactivity (HPR) and recurrent ischemic stroke (RIS). Methods: Genotype, methylation, and mRNA of PEAR1 rs12041331 were detected in patients with cerebral ischemia, for the analysis of the effect of PEAR1 rs12041331 on HPR and RIS. Results: The major G allele of PEAR1 rs12041331 was associated with hypermethylation, which was associated with HPR. This link was not observed for RIS. Conclusions: The PEAR1 rs12041331 genetic polymorphism and DNA methylation may be among the genetic factors affecting HPR. The correlation between PEAR1 and RIS needs to be studied further.
引用
收藏
页码：518 / 522
页数：5
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