Risk Factors of Deep Vein Thrombosis in Adults with Acute Compartment Syndrome Following Lower Extremity Fractures

被引:5
作者
Yang, Shuo [1 ,2 ]
Wang, Tao [1 ,2 ]
Long, Yubin [1 ,2 ,3 ]
Guo, Junfei [2 ]
Hou, Zhiyong [1 ,2 ,4 ]
机构
[1] Third Hosp Hebei Med Univ, Dept Orthopaed Surg, Shijiazhuang, Hebei, Peoples R China
[2] Orthopaed Res Inst Hebei Prov, Shijiazhuang 050051, Hebei, Peoples R China
[3] Baoding First Cent Hosp, Dept Orthoped 3, Baoding, Hebei, Peoples R China
[4] Third Hosp Hebei Med Univ, NHC Key Lab Intelligent Orthopaed Equipment, Shijiazhuang, Hebui, Peoples R China
关键词
acute compartment syndrome; lower extremity fractures; deep venous thrombosis; multiple fractures; body mass index; fibrin degradation products; VENOUS THROMBOEMBOLISM; D-DIMER; PREOPERATIVE PREVALENCE; HIP FRACTURE; OBESITY; DIAGNOSIS;
D O I
10.1177/10760296231165053
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
This study aimed to identify the risk factors of deep vein thrombosis (DVT) in adults with acute compartment syndrome (ACS) following lower extremity fractures. We collected data on adults with ACS following lower extremity fractures in our hospital from November 2013 to January 2021. Patients were divided into the DVT group and the non-DVT group according to whether they had DVT or not. The demographics, comorbidities, and admission laboratory examinations were computed by univariate analysis, logistic regression analysis, and receiver operating characteristic (ROC) curve analysis. In our study, the rate of DVT (26 of 110) was 23.6%. Univariate analysis showed that numerous factors were associated with the formation of DVT. Logistic regression analysis showed that patients with multiple fractures (P = .015, OR = 5.688), patients with a history of hypertension (P = .011, OR = 16.673), and patients with a higher BMI (P = .008, OR = 1.950) and FDP (P = .013, OR = 1.031) were relevant predictors of DVT. ROC curve analysis indicated 24.73 kg/m(2) and 28.33 mu g/mL were the cutoff values of BMI and FDP to predict the DVT, respectively. Furthermore, the combination of BMI and FDP had the highest diagnostic accuracy. Our findings identified multiple fractures, BMI, and FDP as independent risk factors for DVT in patients with ACS following lower extremity fractures and determined the cutoff values of BMI and FDP, helping us individualize the assessment of the risk of DVT to manage early targeted interventions.
引用
收藏
页数:10
相关论文
共 41 条
[1]   Elevated D-Dimer Is Not Predictive of Symptomatic Deep Venous Thrombosis After Total Joint Arthroplasty [J].
An, Thomas J. ;
Engstrom, Stephen M. ;
Oelsner, William K. ;
Benvenuti, Michael A. ;
Polkowski, Gregory G. ;
Schoenecker, Jonathan G. .
JOURNAL OF ARTHROPLASTY, 2016, 31 (10) :2269-2272
[2]   The value of FDP/FIB and D-dimer/FIB ratios in predicting high-risk APL-related thrombosis [J].
Bai, Yanliang ;
Shi, Mingyue ;
Yang, Xiawan ;
Zhang, Wanjun ;
Yang, Ruyu ;
Wei, Xiuli ;
Wei, Xudong ;
Duan, Lijuan ;
Wang, Chenghua ;
Mi, Ruihua ;
Ahmed, Hafiz Abdul Waqas ;
Huo, Lei ;
Chen, Yuqing ;
Xu, Fangfang ;
Wu, Depei ;
Sun, Kai .
LEUKEMIA RESEARCH, 2019, 79 :34-37
[3]   Preoperative anemia and total hospitalization time are the independent factors of preoperative deep venous thromboembolism in Chinese elderly undergoing hip surgery [J].
Feng, Long ;
Xu, Longhe ;
Yuan, Weixiu ;
Xu, Zhipeng ;
Feng, Zeguo ;
Zhang, Hong .
BMC ANESTHESIOLOGY, 2020, 20 (01)
[4]   Multiple Lower-extremity and Pelvic Fractures Increase Pulmonary Embolus Risk [J].
Godzik, Jakub ;
McAndrew, Christopher M. ;
Morshed, Saam ;
Kandemir, Utku ;
Kelly, Michael P. .
ORTHOPEDICS, 2014, 37 (06) :E517-E524
[5]   Acute compartment syndrome Cause, diagnosis, and new viewpoint [J].
Guo, Jialiang ;
Yin, Yingchao ;
Jin, Lin ;
Zhang, Ruipeng ;
Hou, Zhiyong ;
Zhang, Yingze .
MEDICINE, 2019, 98 (27)
[6]   Smoking and abdominal obesity -: Risk factors for venous thromboembolism among middle-aged Men:: "The study of men born in 1913" [J].
Hansson, PO ;
Ericksson, H ;
Welin, L ;
Svärdsudd, K ;
Wilhelmsen, L .
ARCHIVES OF INTERNAL MEDICINE, 1999, 159 (16) :1886-1890
[7]   Effect of delayed admission to the hospital on the preoperative prevalence of deep-vein thrombosis associated with fractures about the hip [J].
Hefley, WF ;
Nelson, CL ;
PuskarichMay, CL .
JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME, 1996, 78A (04) :581-583
[8]   D-dimer kit with a High FDP/D-Dimer Ratio is Useful for Diagnosing Thrombotic Diseases [J].
Ikeda, Nozomi ;
Wada, Hideo ;
Ichikawa, Yuhuko ;
Ezaki, Minoru ;
Tanaka, Motoko ;
Hiromori, Shinya ;
Shiraki, Katsuya ;
Moritani, Isao ;
Yamamoto, Akitaka ;
Shimpo, Hideto ;
Shimaoka, Motomu .
CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS, 2022, 28
[9]  
Jing H., 2018, CHINESE J GEN SURG, V27, P1531, DOI [10.7659/j.issn.1005-6947.2018.12.006, DOI 10.7659/J.ISSN.1005-6947.2018.12.006]
[10]   Effect of increasing serum albumin on plasma D-dimer, von Willebrand factor, and platelet aggregation in CAPD patients [J].
Kim, SB ;
Chi, HS ;
Park, JS ;
Hong, CD ;
Yang, WS .
AMERICAN JOURNAL OF KIDNEY DISEASES, 1999, 33 (02) :312-317