Cell-In-Cell Structures in Early Breast Cancer Are Prognostically Valuable

被引：12

作者：

Bauer, Mareike F. ^{[1
,2
]}

Hildebrand, Laura S. ^{[1
,2
]}

Rosahl, Marie-Charlotte ^{[1
,2
]}

Erber, Ramona ^{[3
]}

Schnellhardt, Soren ^{[1
,2
]}

Buettner-Herold, Maike ^{[4
]}

Putz, Florian ^{[1
,2
]}

Ott, Oliver J. ^{[1
,2
]}

Hack, Carolin C. ^{[2
,5
]}

Fietkau, Rainer ^{[1
,2
]}

Distel, Luitpold ^{[1
,2
]}

机构：

[1] Friedrich Alexander Univ Erlangen Nurnberg FAU, Univ Klinikum Erlangen, Dept Radiat Oncol, Univ Str 27, D-91054 Erlangen, Germany

[2] Friedrich Alexander Univ Erlangen Nurnberg FAU, Univ Klinikum Erlangen, Comprehens Canc Ctr Erlangen EMN CCC ER EMN, D-91054 Erlangen, Germany

[3] Friedrich Alexander Univ Erlangen Nurnberg FAU, Univ Klinikum Erlangen, Inst Pathol, Comprehens Canc Ctr Erlangen EMN, Krankenhausstr 8-10, D-91054 Erlangen, Germany

[4] Friedrich Alexander Univ Erlangen Nurnberg FAU, Univ Klinikum Erlangen, Inst Pathol, Dept Nephropathol, Krankenhausstr 8-10, D-91054 Erlangen, Germany

[5] Friedrich Alexander Univ Erlangen Nurnberg FAU, Univ Klinikum Erlangen, Dept Gynecol, Univ Str 21-23, D-91054 Erlangen, Germany

来源：

CELLS | 2023年 / 12卷 / 01期

关键词：

cell-in-cell; breast cancer; non-professional phagocytosis; ionizing radiation; accelerated partial breast irradiation; radiotherapy; BRACHYTHERAPY; IRRADIATION; CANNIBALISM; ENTOSIS;

D O I：

10.3390/cells12010081

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Cell-in-cell (CIC) structures in breast cancer have so far been studied in a small inhomogeneous patient population, suggesting the prognostic importance of CIC. In the present study, we focused on CIC in early hormone-sensitive breast cancer. With in vitro co-culture experiments, we compared the homotypic phagocytic capacity of two breast cancer cell lines to that of primary human fibroblasts. Afterward, we studied 601 tissue specimens from 147 patients participating in an institutional accelerated partial breast irradiation (APBI) phase II trial. Both breast cancer cell lines performed non-professional phagocytosis at a higher rate than primary human fibroblasts. In this study cohort, 93.2% of the patients had T1 tumours, and 6.8% had T2 tumours. CIC was found in 61.2% of the patients, with a CIC rate ranging from <1/mm(2) to 556.5/mm(2) with a mean of 30.9/mm(2) +/- 68.4/mm(2). CIC structures were prognostically favourable for local recurrence-free survival and disease-free survival. Regarding metastasis-free survival, CIC-positive patients had an unfavourable prognosis. Subgroup analysis indicated a correlation between a high proliferation index and high CIC rates. CIC had the highest prognostic value in young breast cancer patients (p = 0.004). With this study, we provide further evidence of CIC as a prognostic marker in breast cancer.

引用

页数：13

共 38 条

[1] Cell-in-cell phenomenon associates with aggressive characteristics and cancer-related mortality in early oral tongue cancer [J].