The apoptotic effect of the Lycopodium clavatum extracts on MCF-7 human breast cancer cells

被引:1
作者
Kucukbagriacik, Yusuf [1 ,2 ]
Dastouri, Mohammadreza [3 ]
Yilmaz, Humeyra [4 ]
Altuntas, Evrim Gunes [5 ,6 ]
机构
[1] Hlth Sci Univ, Gulhane Fac Med, Dept Biophys, Ankara, Turkiye
[2] Yozgat Bozok Univ, Sch Med, Yozgat, Turkiye
[3] Ankara Medipol Univ, Sch Med, Fac Med Biol, Ankara, Turkiye
[4] Ankara Yildirim Beyazit Univ, Inst Hlth Sci, Dept Med Biol, Ankara, Turkiye
[5] Ankara Univ, Biotechnol Inst, Ankara, Turkiye
[6] Ankara Univ, SSBOTEK, Ankara, Turkiye
关键词
Lycopodium clavatum extract; Cytotoxicity; Apoptosis; Human breast cancer; MCF-7; METASTASIS; ACTIVATION;
D O I
10.1007/s12032-023-02159-7
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Breast cancer is a significant health problem worldwide, and the search for effective treatments is critical. Side effects of cancer treatments such as surgery, radiotherapy, and chemotherapy reduce the patient's standard of living. Recently, natural compounds from plants have gained attention as potential anticancer agents due to their safety, low toxicity, and potential efficacy. Lycopodium Clavatum (LC) is an herb abundant in tropical regions and Europe and is known for its various medicinal properties. In this study, we investigated the cytotoxic and apoptotic effects of LC Water Extract (LC -WE) and LC Ethanol Extract (LC -EE) plant extracts on MCF-7 human breast cancer cells. Our results showed that LC treatment led to a dose and time -dependent cytotoxic effect on MCF-7 cells, indicating its potential as an anticancer agent against human breast cancer. Additionally, we observed that LC treatment activated apoptosis-related proteins, including BAX, Caspase-3, and Caspase-9. These results suggest that LC may induce apoptosis as a mechanism underlying its cytotoxic effect on MCF-7 human breast cancer cells. Previous studies have shown the anti -cancer potential of LC against different types of cancer. However, the anti -cancer effect of LC on human breast cancer cells has not been investigated to date. Therefore, our study provides novel insights into the potential of LC as an anti -cancer agent against breast cancer. Overall, our results highlight the potential of LC as a promising natural compound for breast cancer treatment. [GRAPHICS] .
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页数:10
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