A case series of intraductal papillary neoplasms of the pancreas and biliary tract: a tertiary center experience

Intraductal papillary neoplasms of the pancreas (IPMN) and biliary tract include the papillary neoplasms arising from the extra and intrahepatic bile ducts, gall bladder and pancreas. There are very few published reports of IPMN. In this series, we have studied clinicopathologic features of 13 patients of IPMN diagnosed in our department from January 2016 to July 2022. The gross and microscopic pathology of these tumors was reviewed including size, appearance, type of epithelial differentiation, dysplasia and presence or absence of invasive component. The cases included intraductal tumors of pancreas (4), gall bladder (3) and intra and extrahepatic biliary tract (6). The majority showed biliary type of epithelial differentiation. Invasive malignancy was seen more frequently in neoplasms of the biliary tract. IPMN patients showed aggressive behavior and mortality. The article highlights detailed gross and histopathologic examination for appropriate diagnosis of these tumors. Importance of adequate sectioning to avoid misdiagnosis of invasive carcinoma is emphasized.