Physical Performance and Skeletal Muscle Transcriptional Adaptations Are Not Impacted by Exercise Training Frequency in Mice with Lower Extremity Peripheral Artery Disease

被引:2
作者
Lavier, Jessica [1 ,2 ]
Bouzourene, Karima [1 ]
Millet, Gregoire P. [2 ]
Mazzolai, Lucia [1 ]
Pellegrin, Maxime [1 ,2 ]
机构
[1] Lausanne Univ Hosp CHUV, Heart & Vessel Dept, Angiol Div, CH-1011 Lausanne, Switzerland
[2] Univ Lausanne, Inst Sport Sci, CH-1015 Lausanne, Switzerland
关键词
exercise training frequency; lower extremity peripheral artery disease; skeletal muscle; gene expression; physical performance; BIOCHEMICAL-CHANGES; THERAPY; REHABILITATION; CLAUDICATION; EXPRESSION; PROGRAMS;
D O I
10.3390/metabo13040562
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Exercise training is an important therapeutic strategy for lower extremity peripheral artery disease (PAD). However, the effects of different exercise frequency on physiological adaptations remain unknown. Thus, this study compared the effects of a 7-week moderate-intensity aerobic training performed either three or five times/week on skeletal muscle gene expression and physical performance in mice with PAD. Hypercholesterolemic male ApoE-deficient mice were subjected to unilateral iliac artery ligation and randomly assigned to sedentary or exercise training regimens either three or five times/week. Physical performance was assessed using a treadmill test to exhaustion. Expression of genes related to glucose and lipid metabolism, mitochondrial biogenesis, muscle fiber-type, angiogenesis, and inflammation was analyzed in non-ischemic and ischemic gastrocnemius muscles by real-time polymerase chain reaction. Physical performance was improved to the same extent in both exercise groups. For gene expression patterns, no statistical differences were observed between three or five times/week exercised mice, both in the non-ischemic and ischemic muscles. Our data show that exercising three to five times a week induces similar beneficial effects on performance. Those results are associated with muscular adaptations that remain identical between the two frequencies.
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页数:14
相关论文
共 42 条
[11]   Aged Nicotinamide Riboside Kinase 2 Deficient Mice Present an Altered Response to Endurance Exercise Training [J].
Deloux, Robin ;
Tannous, Cynthia ;
Ferry, Arnaud ;
Li, Zhenlin ;
Mericskay, Mathias .
FRONTIERS IN PHYSIOLOGY, 2018, 9
[12]   Physical Training Leads to Remodeling of Diaphragm Muscle in Asthma Model [J].
Durigan, J. L. Q. ;
Peviani, S. M. ;
Russo, T. L. ;
Duarte, A. C. ;
Vieira, R. P. ;
Martins, M. A. ;
Carvalho, C. R. F. ;
Salvini, T. F. .
INTERNATIONAL JOURNAL OF SPORTS MEDICINE, 2009, 30 (06) :430-434
[13]   Supervised walking therapy in patients with intermittent claudication [J].
Fakhry, Farzin ;
van de Luijtgaarden, Koen M. ;
Bax, Leon ;
den Hoed, P. Ted ;
Hunink, M. G. Myriam ;
Rouwet, Ellen V. ;
Spronk, Sandra .
JOURNAL OF VASCULAR SURGERY, 2012, 56 (04) :1132-1142
[14]   Muscle molecular adaptations to endurance exercise training are conditioned by glycogen availability: a proteomics-based analysis in the McArdle mouse model [J].
Fiuza-Luces, Carmen ;
Santos-Lozano, Alejandro ;
Llavero, Francisco ;
Campo, Rocio ;
Nogales-Gadea, Gisela ;
Diez-Bermejo, Jorge ;
Baladron, Carlos ;
Gonzalez-Murillo, Frica ;
Arenas, Joaquin ;
Martin, Miguel A. ;
Andreu, Antoni L. ;
Pinos, Tomas ;
Galvez, Beatriz G. ;
Lopez, Juan A. ;
Vazquez, Jesus ;
Zugaza, Jose L. ;
Lucia, Alejandro .
JOURNAL OF PHYSIOLOGY-LONDON, 2018, 596 (06) :1035-1061
[15]   EXERCISE REHABILITATION PROGRAMS FOR THE TREATMENT OF CLAUDICATION PAIN - A METAANALYSIS [J].
GARDNER, AW ;
POEHLMAN, ET .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1995, 274 (12) :975-980
[16]  
Gerhard-Herman MD, 2017, J AM COLL CARDIOL, V69, pE71, DOI [10.1016/j.jacc.2016.11.007, 10.1161/CIR.0000000000000471]
[17]   PGC-1α affects aging-related changes in muscle and motor function by modulating specific exercise-mediated changes in old mice [J].
Gill, Jonathan F. ;
Santos, Gesa ;
Schnyder, Svenia ;
Handschin, Christoph .
AGING CELL, 2018, 17 (01)
[18]   The monocarboxylate transporter familyuRole and regulation [J].
Halestrap, Andrew P. ;
Wilson, Marieangela C. .
IUBMB LIFE, 2012, 64 (02) :109-119
[19]   A Systematic Review of the Uptake and Adherence Rates to Supervised Exercise Programs in Patients with Intermittent Claudication [J].
Harwood, Amy-Elizabeth ;
Smith, George E. ;
Cayton, Thomas ;
Broadbent, Edward ;
Chetter, Ian C. .
ANNALS OF VASCULAR SURGERY, 2016, 34 :280-289
[20]   Effects of experimental type 1 diabetes and exercise training on angiogenic gene expression and capillarization in skeletal muscle [J].
Kivela, Riikka ;
Silvennoinen, Mika ;
Touvra, Anna-Maria ;
Lehti, T. Maarit ;
Kainulainen, Heikki ;
Vihko, Veikko .
FASEB JOURNAL, 2006, 20 (09) :1570-+