Physical Performance and Skeletal Muscle Transcriptional Adaptations Are Not Impacted by Exercise Training Frequency in Mice with Lower Extremity Peripheral Artery Disease

被引:2
作者
Lavier, Jessica [1 ,2 ]
Bouzourene, Karima [1 ]
Millet, Gregoire P. [2 ]
Mazzolai, Lucia [1 ]
Pellegrin, Maxime [1 ,2 ]
机构
[1] Lausanne Univ Hosp CHUV, Heart & Vessel Dept, Angiol Div, CH-1011 Lausanne, Switzerland
[2] Univ Lausanne, Inst Sport Sci, CH-1015 Lausanne, Switzerland
关键词
exercise training frequency; lower extremity peripheral artery disease; skeletal muscle; gene expression; physical performance; BIOCHEMICAL-CHANGES; THERAPY; REHABILITATION; CLAUDICATION; EXPRESSION; PROGRAMS;
D O I
10.3390/metabo13040562
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Exercise training is an important therapeutic strategy for lower extremity peripheral artery disease (PAD). However, the effects of different exercise frequency on physiological adaptations remain unknown. Thus, this study compared the effects of a 7-week moderate-intensity aerobic training performed either three or five times/week on skeletal muscle gene expression and physical performance in mice with PAD. Hypercholesterolemic male ApoE-deficient mice were subjected to unilateral iliac artery ligation and randomly assigned to sedentary or exercise training regimens either three or five times/week. Physical performance was assessed using a treadmill test to exhaustion. Expression of genes related to glucose and lipid metabolism, mitochondrial biogenesis, muscle fiber-type, angiogenesis, and inflammation was analyzed in non-ischemic and ischemic gastrocnemius muscles by real-time polymerase chain reaction. Physical performance was improved to the same extent in both exercise groups. For gene expression patterns, no statistical differences were observed between three or five times/week exercised mice, both in the non-ischemic and ischemic muscles. Our data show that exercising three to five times a week induces similar beneficial effects on performance. Those results are associated with muscular adaptations that remain identical between the two frequencies.
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页数:14
相关论文
共 42 条
[1]   2017 ESC Guidelines on the Diagnosis and Treatment of Peripheral Arterial Diseases, in collaboration with the European Society for Vascular Surgery (ESVS) [J].
Aboyans, Victor ;
Ricco, Jean-Baptiste ;
Bartelink, Marie-Louise E. L. ;
Bjorck, Martin ;
Brodmann, Marianne ;
Cohnert, Tina ;
Collet, Jean-Philippe ;
Czerny, Martin ;
De Carlo, Marco ;
Debus, Sebastian ;
Espinola-Klein, Christine ;
Kahan, Thomas ;
Kownator, Serge ;
Mazzolai, Lucia ;
Naylor, A. Ross ;
Roffi, Marco ;
Roether, Joachim ;
Sprynger, Muriel ;
Tendera, Michal ;
Tepe, Gunnar ;
Venermo, Maarit ;
Vlachopoulos, Charalambos ;
Desormais, Ileana .
EUROPEAN HEART JOURNAL, 2018, 39 (09) :763-+
[2]   The effects of different training modalities on monocarboxylate transporters MCT1 and MCT4, hypoxia inducible factor-1α (HIF-1α), and PGC-1α gene expression in rat skeletal muscles [J].
Ahmadi, Akbar ;
Sheikholeslami-Vatani, Dariush ;
Ghaeeni, Saeed ;
Baazm, Maryam .
MOLECULAR BIOLOGY REPORTS, 2021, 48 (03) :2153-2161
[3]   Revascularization and muscle adaptation to limb demand ischemia in diet-induced obese mice [J].
Albadawi, Hassan ;
Tzika, A. Aria ;
Rask-Madsen, Christian ;
Crowley, Lindsey M. ;
Koulopoulos, Michael W. ;
Yoo, Hyung-Jin ;
Watkins, Michael T. .
JOURNAL OF SURGICAL RESEARCH, 2016, 205 (01) :49-58
[4]   Walking Training Improves Systemic and Local Pathophysiological Processes in Intermittent Claudication [J].
Andrade-Lima, Aluisio ;
Silva Junior, Natan ;
Chehuen, Marcel ;
Miyasato, Roberto ;
Souza, Rodrigo W. A. ;
Leicht, Anthony S. ;
Brum, Patricia C. ;
de Oliveira, Edilamar M. ;
Wolosker, Nelson ;
Forjaz, Claudia L. M. .
EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY, 2021, 61 (06) :954-963
[5]  
Bartalucci A, 2012, HISTOL HISTOPATHOL, V27, P753, DOI 10.14670/HH-27.753
[6]   The Science and Translation of Lactate Shuttle Theory [J].
Brooks, George A. .
CELL METABOLISM, 2018, 27 (04) :757-785
[7]   Electric Pulse Stimulation of Cultured Murine Muscle Cells Reproduces Gene Expression Changes of Trained Mouse Muscle [J].
Burch, Nathalie ;
Arnold, Anne-Sophie ;
Item, Flurin ;
Summermatter, Serge ;
Santos, Gesa Brochmann Santana ;
Christe, Martine ;
Boutellier, Urs ;
Toigo, Marco ;
Handschin, Christoph .
PLOS ONE, 2010, 5 (06)
[8]   Multimodal Supervised Exercise Significantly Improves Walking Performances Without Changing Hemodynamic Parameters in Patients With Symptomatic Lower Extremity Peripheral Artery Disease [J].
Calanca, Luca ;
Lanzi, Stefano ;
Ney, Barbara ;
Berchtold, Andre ;
Mazzolai, Lucia .
VASCULAR AND ENDOVASCULAR SURGERY, 2020, 54 (07) :605-611
[9]   Daily running enhances molecular and physiological circadian rhythms in skeletal muscle [J].
Casanova-Vallve, Nuria ;
Duglan, Drew ;
Vaughan, Megan E. ;
Pariollaud, Marie ;
Handzlik, Michal K. ;
Fan, Weiwei ;
Yu, Ruth T. ;
Liddle, Christopher ;
Downes, Michael ;
Delezie, Julien ;
Mello, Rebecca ;
Chan, Alanna B. ;
Westermark, Pal O. ;
Metallo, Christian M. ;
Evans, Ronald M. ;
Lamia, Katja A. .
MOLECULAR METABOLISM, 2022, 61
[10]   Peripheral Arterial Disease [J].
Conte, Sean M. ;
Vale, Peter R. .
HEART LUNG AND CIRCULATION, 2018, 27 (04) :427-432