Physical Performance and Skeletal Muscle Transcriptional Adaptations Are Not Impacted by Exercise Training Frequency in Mice with Lower Extremity Peripheral Artery Disease
Exercise training is an important therapeutic strategy for lower extremity peripheral artery disease (PAD). However, the effects of different exercise frequency on physiological adaptations remain unknown. Thus, this study compared the effects of a 7-week moderate-intensity aerobic training performed either three or five times/week on skeletal muscle gene expression and physical performance in mice with PAD. Hypercholesterolemic male ApoE-deficient mice were subjected to unilateral iliac artery ligation and randomly assigned to sedentary or exercise training regimens either three or five times/week. Physical performance was assessed using a treadmill test to exhaustion. Expression of genes related to glucose and lipid metabolism, mitochondrial biogenesis, muscle fiber-type, angiogenesis, and inflammation was analyzed in non-ischemic and ischemic gastrocnemius muscles by real-time polymerase chain reaction. Physical performance was improved to the same extent in both exercise groups. For gene expression patterns, no statistical differences were observed between three or five times/week exercised mice, both in the non-ischemic and ischemic muscles. Our data show that exercising three to five times a week induces similar beneficial effects on performance. Those results are associated with muscular adaptations that remain identical between the two frequencies.
机构:
Massachusetts Gen Hosp, Dept Surg, Div Vasc & Endovasc Surg, Boston, MA 02114 USA
Harvard Med Sch, Boston, MA USAMassachusetts Gen Hosp, Dept Surg, Div Vasc & Endovasc Surg, Boston, MA 02114 USA
Albadawi, Hassan
;
Tzika, A. Aria
论文数: 0引用数: 0
h-index: 0
机构:
Harvard Med Sch, Boston, MA USA
Massachusetts Gen Hosp, Dept Surg, Shriners Burns Inst, Boston, MA 02114 USAMassachusetts Gen Hosp, Dept Surg, Div Vasc & Endovasc Surg, Boston, MA 02114 USA
Tzika, A. Aria
;
Rask-Madsen, Christian
论文数: 0引用数: 0
h-index: 0
机构:
Harvard Med Sch, Boston, MA USA
Joslin Diabet Ctr, Sect Vasc Cell Biol, Boston, MA 02215 USAMassachusetts Gen Hosp, Dept Surg, Div Vasc & Endovasc Surg, Boston, MA 02114 USA
Rask-Madsen, Christian
;
Crowley, Lindsey M.
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h-index: 0
机构:
Massachusetts Gen Hosp, Dept Surg, Div Vasc & Endovasc Surg, Boston, MA 02114 USAMassachusetts Gen Hosp, Dept Surg, Div Vasc & Endovasc Surg, Boston, MA 02114 USA
Crowley, Lindsey M.
;
Koulopoulos, Michael W.
论文数: 0引用数: 0
h-index: 0
机构:
Massachusetts Gen Hosp, Dept Surg, Div Vasc & Endovasc Surg, Boston, MA 02114 USAMassachusetts Gen Hosp, Dept Surg, Div Vasc & Endovasc Surg, Boston, MA 02114 USA
Koulopoulos, Michael W.
;
Yoo, Hyung-Jin
论文数: 0引用数: 0
h-index: 0
机构:
Massachusetts Gen Hosp, Dept Surg, Div Vasc & Endovasc Surg, Boston, MA 02114 USAMassachusetts Gen Hosp, Dept Surg, Div Vasc & Endovasc Surg, Boston, MA 02114 USA
Yoo, Hyung-Jin
;
Watkins, Michael T.
论文数: 0引用数: 0
h-index: 0
机构:
Massachusetts Gen Hosp, Dept Surg, Div Vasc & Endovasc Surg, Boston, MA 02114 USA
Harvard Med Sch, Boston, MA USAMassachusetts Gen Hosp, Dept Surg, Div Vasc & Endovasc Surg, Boston, MA 02114 USA
机构:
Scripps Res, Dept Mol Med, La Jolla, CA 92037 USA
Univ Calif San Diego, Dept Orthoped Surg, San Diego, CA 92093 USAScripps Res, Dept Mol Med, La Jolla, CA 92037 USA
Casanova-Vallve, Nuria
;
Duglan, Drew
论文数: 0引用数: 0
h-index: 0
机构:
Scripps Res, Dept Mol Med, La Jolla, CA 92037 USA
Scripps Res, Dept Commun, La Jolla, CA 92037 USAScripps Res, Dept Mol Med, La Jolla, CA 92037 USA
Duglan, Drew
;
Vaughan, Megan E.
论文数: 0引用数: 0
h-index: 0
机构:
Scripps Res, Dept Mol Med, La Jolla, CA 92037 USAScripps Res, Dept Mol Med, La Jolla, CA 92037 USA
Vaughan, Megan E.
;
Pariollaud, Marie
论文数: 0引用数: 0
h-index: 0
机构:
Scripps Res, Dept Mol Med, La Jolla, CA 92037 USAScripps Res, Dept Mol Med, La Jolla, CA 92037 USA
Pariollaud, Marie
;
Handzlik, Michal K.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif La Jolla, Dept Bioengn, La Jolla, CA 92093 USA
Salk Inst Biol Studies, Mol & Cell Biol Lab, San Diego, CA 92037 USAScripps Res, Dept Mol Med, La Jolla, CA 92037 USA
Handzlik, Michal K.
;
Fan, Weiwei
论文数: 0引用数: 0
h-index: 0
机构:
Salk Inst Biol Studies, Mol & Cell Biol Lab, La Jolla, CA 92037 USAScripps Res, Dept Mol Med, La Jolla, CA 92037 USA
Fan, Weiwei
;
Yu, Ruth T.
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h-index: 0
机构:
Salk Inst Biol Studies, Mol & Cell Biol Lab, La Jolla, CA 92037 USAScripps Res, Dept Mol Med, La Jolla, CA 92037 USA
Yu, Ruth T.
;
Liddle, Christopher
论文数: 0引用数: 0
h-index: 0
机构:
Westmead Inst Med Res, Storr Liver Ctr, Westmead, NSW 2145, Australia
Univ Sydney, Westmead Hosp, Sch Med, Westmead, NSW 2145, AustraliaScripps Res, Dept Mol Med, La Jolla, CA 92037 USA
Liddle, Christopher
;
Downes, Michael
论文数: 0引用数: 0
h-index: 0
机构:
Salk Inst Biol Studies, Mol & Cell Biol Lab, La Jolla, CA 92037 USAScripps Res, Dept Mol Med, La Jolla, CA 92037 USA
Downes, Michael
;
Delezie, Julien
论文数: 0引用数: 0
h-index: 0
机构:
Scripps Res, Dept Mol Med, La Jolla, CA 92037 USAScripps Res, Dept Mol Med, La Jolla, CA 92037 USA
Delezie, Julien
;
Mello, Rebecca
论文数: 0引用数: 0
h-index: 0
机构:
Scripps Res, Dept Mol Med, La Jolla, CA 92037 USAScripps Res, Dept Mol Med, La Jolla, CA 92037 USA
Mello, Rebecca
;
Chan, Alanna B.
论文数: 0引用数: 0
h-index: 0
机构:
Scripps Res, Dept Mol Med, La Jolla, CA 92037 USAScripps Res, Dept Mol Med, La Jolla, CA 92037 USA
Chan, Alanna B.
;
Westermark, Pal O.
论文数: 0引用数: 0
h-index: 0
机构:
Res Inst Farm Anim Biol FBN, D-18196 Dummerstorf, GermanyScripps Res, Dept Mol Med, La Jolla, CA 92037 USA
Westermark, Pal O.
;
Metallo, Christian M.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif La Jolla, Dept Bioengn, La Jolla, CA 92093 USAScripps Res, Dept Mol Med, La Jolla, CA 92037 USA
Metallo, Christian M.
;
Evans, Ronald M.
论文数: 0引用数: 0
h-index: 0
机构:
Salk Inst Biol Studies, Mol & Cell Biol Lab, La Jolla, CA 92037 USAScripps Res, Dept Mol Med, La Jolla, CA 92037 USA
Evans, Ronald M.
;
Lamia, Katja A.
论文数: 0引用数: 0
h-index: 0
机构:
Scripps Res, Dept Mol Med, La Jolla, CA 92037 USAScripps Res, Dept Mol Med, La Jolla, CA 92037 USA
机构:
Massachusetts Gen Hosp, Dept Surg, Div Vasc & Endovasc Surg, Boston, MA 02114 USA
Harvard Med Sch, Boston, MA USAMassachusetts Gen Hosp, Dept Surg, Div Vasc & Endovasc Surg, Boston, MA 02114 USA
Albadawi, Hassan
;
Tzika, A. Aria
论文数: 0引用数: 0
h-index: 0
机构:
Harvard Med Sch, Boston, MA USA
Massachusetts Gen Hosp, Dept Surg, Shriners Burns Inst, Boston, MA 02114 USAMassachusetts Gen Hosp, Dept Surg, Div Vasc & Endovasc Surg, Boston, MA 02114 USA
Tzika, A. Aria
;
Rask-Madsen, Christian
论文数: 0引用数: 0
h-index: 0
机构:
Harvard Med Sch, Boston, MA USA
Joslin Diabet Ctr, Sect Vasc Cell Biol, Boston, MA 02215 USAMassachusetts Gen Hosp, Dept Surg, Div Vasc & Endovasc Surg, Boston, MA 02114 USA
Rask-Madsen, Christian
;
Crowley, Lindsey M.
论文数: 0引用数: 0
h-index: 0
机构:
Massachusetts Gen Hosp, Dept Surg, Div Vasc & Endovasc Surg, Boston, MA 02114 USAMassachusetts Gen Hosp, Dept Surg, Div Vasc & Endovasc Surg, Boston, MA 02114 USA
Crowley, Lindsey M.
;
Koulopoulos, Michael W.
论文数: 0引用数: 0
h-index: 0
机构:
Massachusetts Gen Hosp, Dept Surg, Div Vasc & Endovasc Surg, Boston, MA 02114 USAMassachusetts Gen Hosp, Dept Surg, Div Vasc & Endovasc Surg, Boston, MA 02114 USA
Koulopoulos, Michael W.
;
Yoo, Hyung-Jin
论文数: 0引用数: 0
h-index: 0
机构:
Massachusetts Gen Hosp, Dept Surg, Div Vasc & Endovasc Surg, Boston, MA 02114 USAMassachusetts Gen Hosp, Dept Surg, Div Vasc & Endovasc Surg, Boston, MA 02114 USA
Yoo, Hyung-Jin
;
Watkins, Michael T.
论文数: 0引用数: 0
h-index: 0
机构:
Massachusetts Gen Hosp, Dept Surg, Div Vasc & Endovasc Surg, Boston, MA 02114 USA
Harvard Med Sch, Boston, MA USAMassachusetts Gen Hosp, Dept Surg, Div Vasc & Endovasc Surg, Boston, MA 02114 USA
机构:
Scripps Res, Dept Mol Med, La Jolla, CA 92037 USA
Univ Calif San Diego, Dept Orthoped Surg, San Diego, CA 92093 USAScripps Res, Dept Mol Med, La Jolla, CA 92037 USA
Casanova-Vallve, Nuria
;
Duglan, Drew
论文数: 0引用数: 0
h-index: 0
机构:
Scripps Res, Dept Mol Med, La Jolla, CA 92037 USA
Scripps Res, Dept Commun, La Jolla, CA 92037 USAScripps Res, Dept Mol Med, La Jolla, CA 92037 USA
Duglan, Drew
;
Vaughan, Megan E.
论文数: 0引用数: 0
h-index: 0
机构:
Scripps Res, Dept Mol Med, La Jolla, CA 92037 USAScripps Res, Dept Mol Med, La Jolla, CA 92037 USA
Vaughan, Megan E.
;
Pariollaud, Marie
论文数: 0引用数: 0
h-index: 0
机构:
Scripps Res, Dept Mol Med, La Jolla, CA 92037 USAScripps Res, Dept Mol Med, La Jolla, CA 92037 USA
Pariollaud, Marie
;
Handzlik, Michal K.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif La Jolla, Dept Bioengn, La Jolla, CA 92093 USA
Salk Inst Biol Studies, Mol & Cell Biol Lab, San Diego, CA 92037 USAScripps Res, Dept Mol Med, La Jolla, CA 92037 USA
Handzlik, Michal K.
;
Fan, Weiwei
论文数: 0引用数: 0
h-index: 0
机构:
Salk Inst Biol Studies, Mol & Cell Biol Lab, La Jolla, CA 92037 USAScripps Res, Dept Mol Med, La Jolla, CA 92037 USA
Fan, Weiwei
;
Yu, Ruth T.
论文数: 0引用数: 0
h-index: 0
机构:
Salk Inst Biol Studies, Mol & Cell Biol Lab, La Jolla, CA 92037 USAScripps Res, Dept Mol Med, La Jolla, CA 92037 USA
Yu, Ruth T.
;
Liddle, Christopher
论文数: 0引用数: 0
h-index: 0
机构:
Westmead Inst Med Res, Storr Liver Ctr, Westmead, NSW 2145, Australia
Univ Sydney, Westmead Hosp, Sch Med, Westmead, NSW 2145, AustraliaScripps Res, Dept Mol Med, La Jolla, CA 92037 USA
Liddle, Christopher
;
Downes, Michael
论文数: 0引用数: 0
h-index: 0
机构:
Salk Inst Biol Studies, Mol & Cell Biol Lab, La Jolla, CA 92037 USAScripps Res, Dept Mol Med, La Jolla, CA 92037 USA
Downes, Michael
;
Delezie, Julien
论文数: 0引用数: 0
h-index: 0
机构:
Scripps Res, Dept Mol Med, La Jolla, CA 92037 USAScripps Res, Dept Mol Med, La Jolla, CA 92037 USA
Delezie, Julien
;
Mello, Rebecca
论文数: 0引用数: 0
h-index: 0
机构:
Scripps Res, Dept Mol Med, La Jolla, CA 92037 USAScripps Res, Dept Mol Med, La Jolla, CA 92037 USA
Mello, Rebecca
;
Chan, Alanna B.
论文数: 0引用数: 0
h-index: 0
机构:
Scripps Res, Dept Mol Med, La Jolla, CA 92037 USAScripps Res, Dept Mol Med, La Jolla, CA 92037 USA
Chan, Alanna B.
;
Westermark, Pal O.
论文数: 0引用数: 0
h-index: 0
机构:
Res Inst Farm Anim Biol FBN, D-18196 Dummerstorf, GermanyScripps Res, Dept Mol Med, La Jolla, CA 92037 USA
Westermark, Pal O.
;
Metallo, Christian M.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif La Jolla, Dept Bioengn, La Jolla, CA 92093 USAScripps Res, Dept Mol Med, La Jolla, CA 92037 USA
Metallo, Christian M.
;
Evans, Ronald M.
论文数: 0引用数: 0
h-index: 0
机构:
Salk Inst Biol Studies, Mol & Cell Biol Lab, La Jolla, CA 92037 USAScripps Res, Dept Mol Med, La Jolla, CA 92037 USA
Evans, Ronald M.
;
Lamia, Katja A.
论文数: 0引用数: 0
h-index: 0
机构:
Scripps Res, Dept Mol Med, La Jolla, CA 92037 USAScripps Res, Dept Mol Med, La Jolla, CA 92037 USA