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- [1] Exploring age-related changes in saccades during cognitive tasks in healthy adultsFRONTIERS IN BEHAVIORAL NEUROSCIENCE, 2024, 17Yang, Hee WonChoe, Jin YeongNoh, Soo RimKim, Jeong LanHan, Ji WonKim, Ki Woong
Neuronal Hyperactivation in EEG Data during Cognitive Tasks Is Related to the Apolipoprotein J/Clusterin Genotype in Nondemented Adults
被引：0
|作者：
Ponomareva, Natalya V.
[1
,2
]
Andreeva, Tatiana V.
[2
,3
,4
]
Protasova, Maria S.
[3
]
Kunizheva, Svetlana S.
[2
,3
]
Kuznetsova, Irina L.
[2
,3
]
Kolesnikova, Ekaterina P.
[1
]
Malina, Daria D.
[1
]
Mitrofanov, Andrey A.
[5
]
Fokin, Vitaly F.
[1
]
Illarioshkin, Sergey N.
[1
]
Rogaev, Evgeny I.
[2
,6
]
机构：
[1] Res Ctr Neurol, Moscow 125367, Russia
[2] Sirius Univ Sci & Technol, Ctr Genet & Life Sci, Soci 354349, Russia
[3] Russian Acad Sci, Vavilov Inst Gen Genet, Moscow 119991, Russia
[4] Lomonosov Moscow State Univ, Fac Biol, Ctr Genet & Genet Technol, Moscow 119192, Russia
[5] Res Ctr Mental Hlth, Moscow 115522, Russia
[6] Umass Chan Med Sch, Dept Psychiat, Shrewsbury, MA 01545 USA
基金：
俄罗斯科学基金会;
关键词：
Alzheimer's disease;
genetic predisposition;
CLU genotype;
EEG;
event-related-desynchronization;
verbal fluency;
aging;
FAMILIAL ALZHEIMERS-DISEASE;
GENOME-WIDE ASSOCIATION;
AMYLOID BETA-PEPTIDE;
RISK VARIANT;
FUNCTIONAL CONNECTIVITY;
IDENTIFIES VARIANTS;
MISSENSE MUTATIONS;
QUANTITATIVE EEG;
MEMORY DECLINE;
ALPHA;
D O I：
10.3390/ijms24076790
中图分类号：
Q5 [生物化学];
Q7 [分子生物学];
学科分类号：
071010 ;
081704 ;
摘要：
The clusterin (CLU) rs11136000 CC genotype is a probable risk factor for Alzheimer's disease (AD). CLU, also known as the apolipoprotein J gene, shares certain properties with the apolipoprotein E (APOE) gene with a well-established relationship with AD. This study aimed to determine whether the electrophysiological patterns of brain activation during the letter fluency task (LFT) depend on CLU genotypes in adults without dementia. Previous studies have shown that LFT performance involves activation of the frontal cortex. We examined EEG alpha1 and alpha2 band desynchronization in the frontal regions during the LFT in 94 nondemented individuals stratified by CLU (rs11136000) genotype. Starting at 30 years of age, CLU CC carriers exhibited more pronounced task-related alpha2 desynchronization than CLU CT&TT carriers in the absence of any differences in LFT performance. In CLU CC carriers, alpha2 desynchronization was significantly correlated with age. Increased task-related activation in individuals at genetic risk for AD may reflect greater "effort" to perform the task and/or neuronal hyperexcitability. The results show that the CLU genotype is associated with neuronal hyperactivation in the frontal cortex during cognitive tasks performances in nondemented individuals, suggesting systematic vulnerability of LFT related cognitive networks in people carrying unfavorable CLU alleles.
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页数：12
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