The present study outlines the fabrication and characterization of pamidronate (PDS) embedded nanofibrous scaffolds based on polycaprolactone/polycaprolactone-polyethyleneglycol-polycaprolactone (PCL/CEC) blends for osteoporotic bone defect management. The electrospinning technique has been utilized to fabricate PDS-loaded scaffolds and the effect of PDS on blends was evaluated by analyzing the surface morphology, wettability, biodegradability, and in vitro cytocompatibility. In vitro studies using human osteosarcoma cell lines (hOS) showed the non-cytotoxic nature of the scaffolds. The fibroporous architecture of PCL/CEC-PDS scaffolds along with their appropriate mechanical properties and ability to support cell growth in vitro suggests their potential for osteoporotic bone defect management.
机构:
Xi An Jiao Tong Univ, State Key Lab Mfg Syst Engn, Xian 710049, Peoples R China
Xi An Jiao Tong Univ, NMPA Key Lab Res & Evaluat Addit Mfg Med Devices, Xian 710049, Peoples R ChinaXi An Jiao Tong Univ, State Key Lab Mfg Syst Engn, Xian 710049, Peoples R China
Zeng, Xiangbin
Meng, Zijie
论文数: 0引用数: 0
h-index: 0
机构:
Xi An Jiao Tong Univ, State Key Lab Mfg Syst Engn, Xian 710049, Peoples R China
Xi An Jiao Tong Univ, NMPA Key Lab Res & Evaluat Addit Mfg Med Devices, Xian 710049, Peoples R ChinaXi An Jiao Tong Univ, State Key Lab Mfg Syst Engn, Xian 710049, Peoples R China
Meng, Zijie
Qiu, Zhennan
论文数: 0引用数: 0
h-index: 0
机构:
Xi An Jiao Tong Univ, State Key Lab Mfg Syst Engn, Xian 710049, Peoples R China
Xi An Jiao Tong Univ, NMPA Key Lab Res & Evaluat Addit Mfg Med Devices, Xian 710049, Peoples R ChinaXi An Jiao Tong Univ, State Key Lab Mfg Syst Engn, Xian 710049, Peoples R China
Qiu, Zhennan
He, Jiankang
论文数: 0引用数: 0
h-index: 0
机构:
Xi An Jiao Tong Univ, State Key Lab Mfg Syst Engn, Xian 710049, Peoples R China
Xi An Jiao Tong Univ, NMPA Key Lab Res & Evaluat Addit Mfg Med Devices, Xian 710049, Peoples R ChinaXi An Jiao Tong Univ, State Key Lab Mfg Syst Engn, Xian 710049, Peoples R China
He, Jiankang
Fan, Jinhai
论文数: 0引用数: 0
h-index: 0
机构:
Xi An Jiao Tong Univ, Affiliated Hosp 1, Dept Urol, Xian, Peoples R ChinaXi An Jiao Tong Univ, State Key Lab Mfg Syst Engn, Xian 710049, Peoples R China
Fan, Jinhai
Li, Dichen
论文数: 0引用数: 0
h-index: 0
机构:
Xi An Jiao Tong Univ, State Key Lab Mfg Syst Engn, Xian 710049, Peoples R China
Xi An Jiao Tong Univ, NMPA Key Lab Res & Evaluat Addit Mfg Med Devices, Xian 710049, Peoples R ChinaXi An Jiao Tong Univ, State Key Lab Mfg Syst Engn, Xian 710049, Peoples R China
机构:
E China Univ Sci & Technol, Sch Mat Sci & Engn, Shanghai 200237, Peoples R ChinaE China Univ Sci & Technol, Sch Mat Sci & Engn, Shanghai 200237, Peoples R China
Gui, Zongyan
Xu, Yuanyuan
论文数: 0引用数: 0
h-index: 0
机构:
E China Univ Sci & Technol, Sch Mat Sci & Engn, Shanghai 200237, Peoples R ChinaE China Univ Sci & Technol, Sch Mat Sci & Engn, Shanghai 200237, Peoples R China
Xu, Yuanyuan
Gao, Yun
论文数: 0引用数: 0
h-index: 0
机构:
E China Univ Sci & Technol, Sch Mat Sci & Engn, Shanghai 200237, Peoples R ChinaE China Univ Sci & Technol, Sch Mat Sci & Engn, Shanghai 200237, Peoples R China
Gao, Yun
Lu, Chong
论文数: 0引用数: 0
h-index: 0
机构:
E China Univ Sci & Technol, Sch Mat Sci & Engn, Shanghai 200237, Peoples R ChinaE China Univ Sci & Technol, Sch Mat Sci & Engn, Shanghai 200237, Peoples R China
Lu, Chong
Cheng, Shujun
论文数: 0引用数: 0
h-index: 0
机构:
E China Univ Sci & Technol, Sch Mat Sci & Engn, Shanghai 200237, Peoples R ChinaE China Univ Sci & Technol, Sch Mat Sci & Engn, Shanghai 200237, Peoples R China
机构:
Islamic Azad Univ, Dept Biomed Engn, Sci & Res Branch, Tehran, IranIslamic Azad Univ, Dept Biomed Engn, Sci & Res Branch, Tehran, Iran
Mehrazin, Mehdi
Asefnejad, Azadeh
论文数: 0引用数: 0
h-index: 0
机构:
Islamic Azad Univ, Dept Biomed Engn, Sci & Res Branch, Tehran, IranIslamic Azad Univ, Dept Biomed Engn, Sci & Res Branch, Tehran, Iran
Asefnejad, Azadeh
Naeimi, Farid
论文数: 0引用数: 0
h-index: 0
机构:
Islamic Azad Univ, Adv Mat Res Ctr, Dept Mat Engn, Najafabad Branch, Najafabad, IranIslamic Azad Univ, Dept Biomed Engn, Sci & Res Branch, Tehran, Iran
机构:
Xi An Jiao Tong Univ, State Key Lab Mfg Syst Engn, Xian 710049, Peoples R China
Xi An Jiao Tong Univ, NMPA Key Lab Res & Evaluat Addit Mfg Med Devices, Xian 710049, Peoples R ChinaXi An Jiao Tong Univ, State Key Lab Mfg Syst Engn, Xian 710049, Peoples R China
Zeng, Xiangbin
Meng, Zijie
论文数: 0引用数: 0
h-index: 0
机构:
Xi An Jiao Tong Univ, State Key Lab Mfg Syst Engn, Xian 710049, Peoples R China
Xi An Jiao Tong Univ, NMPA Key Lab Res & Evaluat Addit Mfg Med Devices, Xian 710049, Peoples R ChinaXi An Jiao Tong Univ, State Key Lab Mfg Syst Engn, Xian 710049, Peoples R China
Meng, Zijie
Qiu, Zhennan
论文数: 0引用数: 0
h-index: 0
机构:
Xi An Jiao Tong Univ, State Key Lab Mfg Syst Engn, Xian 710049, Peoples R China
Xi An Jiao Tong Univ, NMPA Key Lab Res & Evaluat Addit Mfg Med Devices, Xian 710049, Peoples R ChinaXi An Jiao Tong Univ, State Key Lab Mfg Syst Engn, Xian 710049, Peoples R China
Qiu, Zhennan
He, Jiankang
论文数: 0引用数: 0
h-index: 0
机构:
Xi An Jiao Tong Univ, State Key Lab Mfg Syst Engn, Xian 710049, Peoples R China
Xi An Jiao Tong Univ, NMPA Key Lab Res & Evaluat Addit Mfg Med Devices, Xian 710049, Peoples R ChinaXi An Jiao Tong Univ, State Key Lab Mfg Syst Engn, Xian 710049, Peoples R China
He, Jiankang
Fan, Jinhai
论文数: 0引用数: 0
h-index: 0
机构:
Xi An Jiao Tong Univ, Affiliated Hosp 1, Dept Urol, Xian, Peoples R ChinaXi An Jiao Tong Univ, State Key Lab Mfg Syst Engn, Xian 710049, Peoples R China
Fan, Jinhai
Li, Dichen
论文数: 0引用数: 0
h-index: 0
机构:
Xi An Jiao Tong Univ, State Key Lab Mfg Syst Engn, Xian 710049, Peoples R China
Xi An Jiao Tong Univ, NMPA Key Lab Res & Evaluat Addit Mfg Med Devices, Xian 710049, Peoples R ChinaXi An Jiao Tong Univ, State Key Lab Mfg Syst Engn, Xian 710049, Peoples R China
机构:
E China Univ Sci & Technol, Sch Mat Sci & Engn, Shanghai 200237, Peoples R ChinaE China Univ Sci & Technol, Sch Mat Sci & Engn, Shanghai 200237, Peoples R China
Gui, Zongyan
Xu, Yuanyuan
论文数: 0引用数: 0
h-index: 0
机构:
E China Univ Sci & Technol, Sch Mat Sci & Engn, Shanghai 200237, Peoples R ChinaE China Univ Sci & Technol, Sch Mat Sci & Engn, Shanghai 200237, Peoples R China
Xu, Yuanyuan
Gao, Yun
论文数: 0引用数: 0
h-index: 0
机构:
E China Univ Sci & Technol, Sch Mat Sci & Engn, Shanghai 200237, Peoples R ChinaE China Univ Sci & Technol, Sch Mat Sci & Engn, Shanghai 200237, Peoples R China
Gao, Yun
Lu, Chong
论文数: 0引用数: 0
h-index: 0
机构:
E China Univ Sci & Technol, Sch Mat Sci & Engn, Shanghai 200237, Peoples R ChinaE China Univ Sci & Technol, Sch Mat Sci & Engn, Shanghai 200237, Peoples R China
Lu, Chong
Cheng, Shujun
论文数: 0引用数: 0
h-index: 0
机构:
E China Univ Sci & Technol, Sch Mat Sci & Engn, Shanghai 200237, Peoples R ChinaE China Univ Sci & Technol, Sch Mat Sci & Engn, Shanghai 200237, Peoples R China
机构:
Islamic Azad Univ, Dept Biomed Engn, Sci & Res Branch, Tehran, IranIslamic Azad Univ, Dept Biomed Engn, Sci & Res Branch, Tehran, Iran
Mehrazin, Mehdi
Asefnejad, Azadeh
论文数: 0引用数: 0
h-index: 0
机构:
Islamic Azad Univ, Dept Biomed Engn, Sci & Res Branch, Tehran, IranIslamic Azad Univ, Dept Biomed Engn, Sci & Res Branch, Tehran, Iran
Asefnejad, Azadeh
Naeimi, Farid
论文数: 0引用数: 0
h-index: 0
机构:
Islamic Azad Univ, Adv Mat Res Ctr, Dept Mat Engn, Najafabad Branch, Najafabad, IranIslamic Azad Univ, Dept Biomed Engn, Sci & Res Branch, Tehran, Iran