Nanofibrous polycaprolactone-polyethylene glycol-based scaffolds embedded with pamidronate: fabrication and characterization

被引：0
作者：
Rajan, Remya K. [1 ]
Chandran, Sunitha [2 ]
John, Annie [3 ]
Parameswaran, Ramesh [1 ]
机构：
[1] Sree Chitra Tirunal Inst Med Sci & Technol, Div Polymer Med Devices, Biomed Technol Wing, Trivandrum, Kerala, India
[2] Sree Chitra Tirunal Inst Med Sci & Technol, TIMED, Biomed Technol Wing, Trivandrum, Kerala, India
[3] Univ Kerala, Dept Biochem, Trivandrum, Kerala, India
来源：
INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS | 2024年 / 73卷 / 01期
关键词：
Drug delivery; electrospinning; osteoporosis; pamidronate; polycaprolactone; FIBER DIAMETER; ELECTROSPUN POLYCAPROLACTONE; COMPOSITE SCAFFOLDS; STEM-CELLS; TISSUE; DIFFERENTIATION; ALENDRONATE; POLYMERS; BEHAVIOR;
D O I：
10.1080/00914037.2022.2124252
中图分类号：
TB3 [工程材料学]; R318.08 [生物材料学];
学科分类号：
0805 ; 080501 ; 080502 ;
摘要：
The present study outlines the fabrication and characterization of pamidronate (PDS) embedded nanofibrous scaffolds based on polycaprolactone/polycaprolactone-polyethyleneglycol-polycaprolactone (PCL/CEC) blends for osteoporotic bone defect management. The electrospinning technique has been utilized to fabricate PDS-loaded scaffolds and the effect of PDS on blends was evaluated by analyzing the surface morphology, wettability, biodegradability, and in vitro cytocompatibility. In vitro studies using human osteosarcoma cell lines (hOS) showed the non-cytotoxic nature of the scaffolds. The fibroporous architecture of PCL/CEC-PDS scaffolds along with their appropriate mechanical properties and ability to support cell growth in vitro suggests their potential for osteoporotic bone defect management.
引用
收藏
页码：61 / 70
页数：10
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