Photochemistry in Medicinal Chemistry and Chemical Biology

被引：12
作者：
Zhu, W. Felix [1 ]
Empel, Claire [2 ]
Pelliccia, Sveva [3 ]
Koenigs, Rene M. [2 ]
Proschak, Ewgenij [1 ,4 ]
Hernandez-Olmos, Victor [4 ]
机构：
[1] Goethe Univ Frankfurt, Inst Pharmaceut Chem, D-60438 Frankfurt, Germany
[2] Rhein Westfal TH Aachen, Inst Organ Chem, D-52074 Aachen, Germany
[3] Univ Naples Federico II, Dept Pharm DoE 2023 2027, I-80131 Naples, Italy
[4] Fraunhofer Inst Translat Med & Pharmacol ITMP, D-60596 Frankfurt, Germany
来源：
JOURNAL OF MEDICINAL CHEMISTRY | 2024年 / 67卷 / 06期
关键词：
VISIBLE-LIGHT PHOTOCATALYSIS; SYNTHETIC PHOTOCHEMISTRY; PHOTODYNAMIC THERAPY; PHOTOCLICK CHEMISTRY; PHOTOREDOX CATALYSIS; AZO DYES; DRUG; PHOTOSENSITIZERS; ORGANOCATALYSIS; FUNCTIONALIZATION;
D O I：
10.1021/acs.jmedchem.3c02109
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Photochemistry has emerged as a transformative force in organic chemistry, significantly expanding the chemical space accessible for medicinal chemistry. Light-induced reactions enable the efficient synthesis of intricate organic structures and have found applications throughout the different stages of the drug discovery and development processes. Moreover, photochemical techniques provide innovative solutions in chemical biology, allowing precise spatiotemporal drug activation and targeted delivery. In this Perspective, we highlight the already numerous remarkable applications and the even more promising future of photochemistry in medicinal chemistry and chemical biology.
引用
收藏
页码：4322 / 4345
页数：24
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