The roles of liver sinusoidal endothelial cells in liver ischemia/reperfusion injury

被引：2
作者：
Deng, Yinzhi [1 ,2 ,3 ]
He, Jianhua [2 ,6 ]
Luo, Hesheng [4 ,5 ]
机构：
[1] Cent Hosp Enshi Tujia & Miao Autonomous Prefecture, Hubei Selenium & Human Hlth Inst, Enshi, Peoples R China
[2] Cent Hosp Enshi Tujia & Miao Autonomous Prefecture, Dept Gastroenterol, Enshi, Peoples R China
[3] Hubei Prov Key Lab Selenium Resources & Bioapplica, Enshi, Peoples R China
[4] Wuhan Univ, Dept Gastroenterol, Renmin Hosp, Wuhan, Peoples R China
[5] Wuhan Univ, Renmin Hosp, Dept Gastroenterol, Wuhan 430060, Hubei, Peoples R China
[6] Cent Hosp Enshi Tujia & Miao Autonomous Prefecture, Dept Gastroenterol, Enshi 445000, Hubei, Peoples R China
来源：
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY | 2024年 / 39卷 / 02期
关键词：
Ischemia/reperfusion injury; Liver; Liver sinusoidal endothelial cells; Sterile inflammatory response; HEPATOCYTE GROWTH-FACTOR; ISCHEMIA-REPERFUSION; HEPATIC ISCHEMIA; STELLATE CELLS; TRANSPLANTATION; SIMVASTATIN; PLATELETS; REGENERATION; DYSFUNCTION; ACTIVATION;
D O I：
10.1111/jgh.16396
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Liver ischemia/reperfusion injury (IRI) is a major complication after partial hepatectomy and liver transplantation and during hypovolemic shock and hypoxia-related diseases. Liver IRI is a current research hotspot. The early stage of liver IRI is characterized by injury and dysfunction of liver sinusoidal endothelial cells (LSECs), which, along with hepatocytes, are the major cells involved in liver injury. In this review, we elaborate on the roles played by LSECs in liver IRI, including the pathological features of LSECs, LSECs exacerbation of the sterile inflammatory response, LSECs interactions with platelets and the promotion of liver regeneration, and the activation of LSECs autophagy. In addition, we discuss the study of LSECs as therapeutic targets for the treatment of liver IRI and the existing problems when applying LSECs in liver IRI research.
引用
收藏
页码：224 / 230
页数：7
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