Key changes in the future clinical application of ultra-high dose rate radiotherapy

被引：1
作者：
Lin, Binwei [1 ]
Fan, Mi [2 ]
Niu, Tingting [2 ]
Liang, Yuwen [2 ]
Xu, Haonan [2 ]
Tang, Wenqiang [2 ]
Du, Xiaobo [1 ]
机构：
[1] Univ Elect Sci & Technol, Mianyang Cent Hosp, Sch Med, Dept Oncol,Natl Hlth Commiss NHC,Key Lab Nucl Tech, Mianyang, Peoples R China
[2] North Sichuan Med Coll, Affiliated Hosp, Dept Oncol, Nanchong, Peoples R China
来源：
FRONTIERS IN ONCOLOGY | 2023年 / 13卷
基金：
中国国家自然科学基金;
关键词：
FLASH-RT; clinical application; simulations; target delineation; treatment plan evaluation; STEREOTACTIC BODY RADIOTHERAPY; RADIATION-THERAPY; FLASH IRRADIATION; BRAIN METASTASES; LUNG; RADIOSURGERY; TOXICITY; PROTOCOL; ABSENCE; CELLS;
D O I：
10.3389/fonc.2023.1244488
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Ultra-high dose rate radiotherapy (FLASH-RT) is an external beam radiotherapy strategy that uses an extremely high dose rate (>= 40 Gy/s). Compared with conventional dose rate radiotherapy (<= 0.1 Gy/s), the main advantage of FLASH-RT is that it can reduce damage of organs at risk surrounding the cancer and retain the anti-tumor effect. An important feature of FLASH-RT is that an extremely high dose rate leads to an extremely short treatment time; therefore, in clinical applications, the steps of radiotherapy may need to be adjusted. In this review, we discuss the selection of indications, simulations, target delineation, selection of radiotherapy technologies, and treatment plan evaluation for FLASH-RT to provide a theoretical basis for future research.
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页数：10
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