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Stimuli-responsive nanocarrier delivery systems for Pt-based antitumor complexes: a review
被引:18
作者:

Wang, Tianshuai
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机构:
Hubei Univ Med, Hubei Key Lab Wudang Local Chinese Med Res, Shiyan 442000, Hubei, Peoples R China
Hubei Univ Med, Coll Pharmaceut Sci, Shiyan 442000, Hubei, Peoples R China Hubei Univ Med, Hubei Key Lab Wudang Local Chinese Med Res, Shiyan 442000, Hubei, Peoples R China

Wu, Chen
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h-index: 0
机构:
Hubei Univ Med, Coll Pharmaceut Sci, Shiyan 442000, Hubei, Peoples R China Hubei Univ Med, Hubei Key Lab Wudang Local Chinese Med Res, Shiyan 442000, Hubei, Peoples R China

Hu, Yanggen
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h-index: 0
机构:
Hubei Univ Med, Hubei Key Lab Wudang Local Chinese Med Res, Shiyan 442000, Hubei, Peoples R China
Hubei Univ Med, Coll Pharmaceut Sci, Shiyan 442000, Hubei, Peoples R China Hubei Univ Med, Hubei Key Lab Wudang Local Chinese Med Res, Shiyan 442000, Hubei, Peoples R China

Zhang, Yan
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h-index: 0
机构:
Hubei Univ Med, Coll Pharmaceut Sci, Shiyan 442000, Hubei, Peoples R China Hubei Univ Med, Hubei Key Lab Wudang Local Chinese Med Res, Shiyan 442000, Hubei, Peoples R China

Ma, Junkai
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h-index: 0
机构:
Hubei Univ Med, Hubei Key Lab Wudang Local Chinese Med Res, Shiyan 442000, Hubei, Peoples R China
Hubei Univ Med, Coll Pharmaceut Sci, Shiyan 442000, Hubei, Peoples R China Hubei Univ Med, Hubei Key Lab Wudang Local Chinese Med Res, Shiyan 442000, Hubei, Peoples R China
机构:
[1] Hubei Univ Med, Hubei Key Lab Wudang Local Chinese Med Res, Shiyan 442000, Hubei, Peoples R China
[2] Hubei Univ Med, Coll Pharmaceut Sci, Shiyan 442000, Hubei, Peoples R China
关键词:
MESOPOROUS SILICA NANOPARTICLES;
NEAR-INFRARED LIGHT;
CONTAINING POLYMER MICELLES;
ANTICANCER DRUG-DELIVERY;
METAL-ORGANIC FRAMEWORKS;
HIFU-TRIGGERED RELEASE;
THERAPEUTIC-EFFICACY;
TARGETED DELIVERY;
CANCER-THERAPY;
IN-VITRO;
D O I:
10.1039/d3ra00866e
中图分类号:
O6 [化学];
学科分类号:
0703 ;
摘要:
Platinum-based anticancer drugs play a crucial role in the clinical treatment of various cancers. However, the application of platinum-based drugs is heavily restricted by their severe toxicity and drug resistance/cross resistance. Various drug delivery systems have been developed to overcome these limitations of platinum-based chemotherapy. Stimuli-responsive nanocarrier drug delivery systems as one of the most promising strategies attract more attention. And huge progress in stimuli-responsive nanocarrier delivery systems of platinum-based drugs has been made. In these systems, a variety of triggers including endogenous and extracorporeal stimuli have been employed. Endogenous stimuli mainly include pH-, thermo-, enzyme- and redox-responsive nanocarriers. Extracorporeal stimuli include light-, magnetic field- and ultrasound responsive nanocarriers. In this review, we present the recent advances in stimuli-responsive drug delivery systems with different nanocarriers for improving the efficacy and reducing the side effects of platinum-based anticancer drugs.
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收藏
页码:16488 / 16511
页数:24
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CNRS CSNSM, Ctr Sci Nucl & Sci Mat, F-91405 Orsay, France RAS, Siberian Branch, VS Sobolev Inst Geol & Mineral, Novosibirsk 630090, Russia

Pessina, G.
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Ist Nazl Fis Nucl, Sez Milano Bicocca, I-20126 Milan, Italy RAS, Siberian Branch, VS Sobolev Inst Geol & Mineral, Novosibirsk 630090, Russia

Poda, D. V.
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Inst Nucl Res, UA-03680 Kiev, Ukraine
CNRS CSNSM, Ctr Sci Nucl & Sci Mat, F-91405 Orsay, France RAS, Siberian Branch, VS Sobolev Inst Geol & Mineral, Novosibirsk 630090, Russia

Shlegel, V. N.
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Nikolaev Inst Inorgan Chem, Novosibirsk 630090, Russia RAS, Siberian Branch, VS Sobolev Inst Geol & Mineral, Novosibirsk 630090, Russia

Tretyak, V. I.
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Inst Nucl Res, UA-03680 Kiev, Ukraine RAS, Siberian Branch, VS Sobolev Inst Geol & Mineral, Novosibirsk 630090, Russia

Velazquez, M.
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Univ Bordeaux, ICMCB, CNRS, F-33608 Pessac, France RAS, Siberian Branch, VS Sobolev Inst Geol & Mineral, Novosibirsk 630090, Russia