Stimuli-responsive nanocarrier delivery systems for Pt-based antitumor complexes: a review

被引:18
作者
Wang, Tianshuai [1 ,2 ]
Wu, Chen [2 ]
Hu, Yanggen [1 ,2 ]
Zhang, Yan [2 ]
Ma, Junkai [1 ,2 ]
机构
[1] Hubei Univ Med, Hubei Key Lab Wudang Local Chinese Med Res, Shiyan 442000, Hubei, Peoples R China
[2] Hubei Univ Med, Coll Pharmaceut Sci, Shiyan 442000, Hubei, Peoples R China
关键词
MESOPOROUS SILICA NANOPARTICLES; NEAR-INFRARED LIGHT; CONTAINING POLYMER MICELLES; ANTICANCER DRUG-DELIVERY; METAL-ORGANIC FRAMEWORKS; HIFU-TRIGGERED RELEASE; THERAPEUTIC-EFFICACY; TARGETED DELIVERY; CANCER-THERAPY; IN-VITRO;
D O I
10.1039/d3ra00866e
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Platinum-based anticancer drugs play a crucial role in the clinical treatment of various cancers. However, the application of platinum-based drugs is heavily restricted by their severe toxicity and drug resistance/cross resistance. Various drug delivery systems have been developed to overcome these limitations of platinum-based chemotherapy. Stimuli-responsive nanocarrier drug delivery systems as one of the most promising strategies attract more attention. And huge progress in stimuli-responsive nanocarrier delivery systems of platinum-based drugs has been made. In these systems, a variety of triggers including endogenous and extracorporeal stimuli have been employed. Endogenous stimuli mainly include pH-, thermo-, enzyme- and redox-responsive nanocarriers. Extracorporeal stimuli include light-, magnetic field- and ultrasound responsive nanocarriers. In this review, we present the recent advances in stimuli-responsive drug delivery systems with different nanocarriers for improving the efficacy and reducing the side effects of platinum-based anticancer drugs.
引用
收藏
页码:16488 / 16511
页数:24
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