Identification of Hub Genes in Neuropathic Pain-induced Depression

被引：0

作者：

Cui, Chun-Yan ^{[1
,2
]}

Liu, Ming-Han ^{[1
,2
]}

Mou, Jian ^{[1
,2
]}

Liao, Si-Jing ^{[1
,2
]}

Liu, Yan ^{[2
]}

Li, Qun ^{[1
]}

Yang, Hai ^{[2
]}

Ren, Ying-Bo ^{[2
]}

Huang, Yue ^{[3
]}

Li, Run ^{[2
]}

Zhang, Ying ^{[1
,2
]}

Liu, Qing ^{[1
,2
,4
]}

机构：

[1] Southwest Med Univ, Dept Pain, Hosp TCM, Luzhou 646000, Sichuan, Peoples R China

[2] Southwest Med Univ, Dept Anesthesiol, Hosp TCM, Luzhou 646000, Sichuan, Peoples R China

[3] Zigong First Peoples Hosp, Dept Anesthesiol, Zi Gong 644099, Sichuan, Peoples R China

[4] Hejiang Tradit Chinese Med Hosp, Luzhou 646000, Sichuan, Peoples R China

来源：

CURRENT BIOINFORMATICS | 2023年 / 18卷 / 10期

关键词：

Neuropathic pain-induced depression; WGCNA; protein-protein interaction (PPI) network analysis; hub genes; novel bioinformatics methods; differentially expressed genes; PROTEIN; 4; CHD4; TRANSFERRIN RECEPTOR; GLANZMANN THROMBASTHENIA; ANTIDEPRESSANT RESPONSE; SOLUBLE INTERLEUKIN-2; CANCER PROGRESSION; CUX1; RESISTANCE; PROMOTES; CELLS;

D O I：

10.2174/1574893618666230614093416

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Introduction Numerous clinical data and animal models demonstrate that many patients with neuropathic pain suffer from concomitant depressive symptoms.Methods Massive evidence from biological experiments has verified that the medial prefrontal cortex (mPFC), prefrontal cortex, hippocampus, and other brain regions play an influential role in the co-morbidity of neuropathic pain and depression, but the mechanism by which neuropathic pain induces depression remains unclear.Results In this study, we mined existing publicly available databases of high-throughput sequencing data intending to identify the differentially expressed genes (DEGs) in the process of neuropathic pain-induced depression.Conclusion This study provides a rudimentary exploration of the mechanism of neuropathic pain-induced depression and provides credible evidence for its management and precaution.

引用

页码：817 / 829

页数：13

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