Extracellular Vesicles in Liver Transplantation: Current Evidence and Future Challenges

被引：3
作者：
De Stefano, Nicola [1 ]
Calleri, Alberto [2 ]
Faini, Angelo Corso [3 ]
Navarro-Tableros, Victor [4 ]
Martini, Silvia [2 ]
Deaglio, Silvia [3 ]
Patrono, Damiano [1 ]
Romagnoli, Renato [1 ]
机构：
[1] Univ Torino, Azienda Osped Univ Citta Salute & Sci Torino, Dept Surg Sci, Gen Surg 2U Liver Transplant Unit, Corso Bramante 88-90, I-10126 Turin, Italy
[2] Univ Turin, Gastrohepatol Unit, Azienda Osped Univ Citta Salute & Sci Torino, I-10126 Turin, Italy
[3] Univ Turin, Immunogenet & Transplant Biol Unit, Azienda Osped Univ Citta Salute & Sci Torino, I-10126 Turin, Italy
[4] Univ Turin, Soc Gest Incubatore Imprese & Trasferimento Tecnol, 2i3T, I-10126 Turin, Italy
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2023年 / 24卷 / 17期
基金：
英国科研创新办公室;
关键词：
extracellular vesicles; liver transplantation; liquid biopsy; hepatocellular carcinoma; rejection; machine perfusion; stem cells; ischemia-reperfusion injury; MESENCHYMAL STEM-CELLS; HEPATOCELLULAR-CARCINOMA RECURRENCE; HYPOTHERMIC MACHINE PERFUSION; STROMAL CELLS; EXOSOMES; BIOMARKERS; INJURY; REJECTION; FULMINANT; MICROVESICLES;
D O I：
10.3390/ijms241713547
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Extracellular vesicles (EVs) are emerging as a promising field of research in liver disease. EVs are small, membrane-bound vesicles that contain various bioactive molecules, such as proteins, lipids, and nucleic acids and are involved in intercellular communication. They have been implicated in numerous physiological and pathological processes, including immune modulation and tissue repair, which make their use appealing in liver transplantation (LT). This review summarizes the current state of knowledge regarding the role of EVs in LT, including their potential use as biomarkers and therapeutic agents and their role in graft rejection. By providing a comprehensive insight into this emerging topic, this research lays the groundwork for the potential application of EVs in LT.
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页数：19
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