Biomarkers selection and mathematical modeling in biological age estimation

被引：28

作者：

Bafei, Solim Essomandan Clemence ^{[1
]}

Shen, Chong ^{[1
]}

机构：

[1] Nanjing Med Univ, Ctr Global Hlth, Sch Publ Hlth, Dept Epidemiol, Nanjing 211166, Jiangsu, Peoples R China

来源：

NPJ AGING | 2023年 / 9卷 / 01期

基金：

中国国家自然科学基金;

关键词：

GENOME-WIDE ASSOCIATION; POLYGENIC RISK SCORE; EPIGENETIC CLOCKS; GENE-EXPRESSION; DNA METHYLATION; NATIONAL-HEALTH; LIFE-SPAN; LONGEVITY; MORTALITY; INDEX;

D O I：

10.1038/s41514-023-00110-8

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Biological age (BA) is important for clinical monitoring and preventing aging-related disorders and disabilities. Clinical and/or cellular biomarkers are measured and integrated in years using mathematical models to display an individual's BA. To date, there is not yet a single or set of biomarker(s) and technique(s) that is validated as providing the BA that reflects the best real aging status of individuals. Herein, a comprehensive overview of aging biomarkers is provided and the potential of genetic variations as proxy indicators of the aging state is highlighted. A comprehensive overview of BA estimation methods is also provided as well as a discussion of their performances, advantages, limitations, and potential approaches to overcome these limitations.

引用

页数：9

共 105 条

[11] How Important Are Genes to Achieve Longevity? [J].

Caruso, Calogero ;

Ligotti, Mattia Emanuela ;

Accardi, Giulia ;

Aiello, Anna ;

Duro, Giovanni ;

Galimberti, Damiano ;

Candore, Giuseppina .

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2022, 23 (10)

[12] An empirical comparative study on biological age estimation algorithms with an application of Work Ability Index (WAI) [J].

Cho, Il Haeng ;

Park, Kyung S. ;

Lim, Chang Joo .

MECHANISMS OF AGEING AND DEVELOPMENT, 2010, 131 (02) :69-78

[13] Tutorial: a guide to performing polygenic risk score analyses [J].

Choi, Shing Wan ;

Mak, Timothy Shin-Heng ;

O'Reilly, Paul F. .

NATURE PROTOCOLS, 2020, 15 (09) :2759-2772

[14] PRSice-2: Polygenic Risk Score software for biobank-scale data [J].

Choi, Shing Wan ;

O'Reilly, Paul F. .

GIGASCIENCE, 2019, 8 (07)

[15] Statistical Distance as a Measure of Physiological Dysregulation Is Largely Robust to Variation in Its Biomarker Composition [J].

Cohen, Alan A. ;

Li, Qing ;

Milot, Emmanuel ;

Leroux, Maxime ;

Faucher, Samuel ;

Morissette-Thomas, Vincent ;

Legault, Veronique ;

Fried, Linda P. ;

Ferrucci, Luigi .

PLOS ONE, 2015, 10 (04)

[16] A novel statistical approach shows evidence for multi-system physiological dysregulation during aging [J].

Cohen, Alan A. ;

Milot, Emmanuel ;

Yong, Jian ;

Seplaki, Christopher L. ;

Fueloep, Tamas ;

Bandeen-Roche, Karen ;

Fried, Linda P. .

MECHANISMS OF AGEING AND DEVELOPMENT, 2013, 134 (3-4) :110-117

[17] Calculating Polygenic Risk Scores (PRS) in UK Biobank: A Practical Guide for Epidemiologists [J].

Collister, Jennifer A. ;

Liu, Xiaonan ;

Clifton, Lei .

FRONTIERS IN GENETICS, 2022, 13

[18] A meta-analysis of genome-wide association studies identifies multiple longevity genes [J].

Deelen, Joris ;

Evans, Daniel S. ;

Arking, Dan E. ;

Tesi, Niccola ;

Nygaard, Marianne ;

Liu, Xiaomin ;

Wojczynski, Mary K. ;

Biggs, Mary L. ;

van Der Spek, Ashley ;

Atzmon, Gil ;

Ware, Erin B. ;

Sarnowski, Chloe ;

Smith, Albert, V ;

Seppala, Ilkka ;

Cordell, Heather J. ;

Dose, Janina ;

Amin, Najaf ;

Arnold, Alice M. ;

Ayers, Kristin L. ;

Barzilai, Nir ;

Becker, Elizabeth J. ;

Beekman, Marian ;

Blanche, Helene ;

Christensen, Kaare ;

Christiansen, Lene ;

Collerton, Joanna C. ;

Cubaynes, Sarah ;

Cummings, Steven R. ;

Davies, Karen ;

Debrabant, Birgit ;

Deleuze, Jean-Francois ;

Duncan, Rachel ;

Faul, Jessica D. ;

Franceschi, Claudio ;

Galan, Pilar ;

Gudnaso, Vilmundur ;

Harris, Tamara B. ;

Huisman, Martijn ;

Hurme, Mikko A. ;

Jagger, Carol ;

Jansen, Iris ;

Jylha, Marja ;

Kahonen, Mika ;

Karasik, David ;

Kardia, Sharon L. R. ;

Kingston, Andrew ;

Kirkwood, Thomas B. L. ;

Launer, Lenore J. ;

Lehtimaki, Terho ;

Lieb, Wolfgang .

NATURE COMMUNICATIONS, 2019, 10 (1)

[19] Genome-wide association meta-analysis of human longevity identifies a novel locus conferring survival beyond 90 years of age [J].

Deelen, Joris ;

Beekman, Marian ;

Uh, Hae-Won ;

Broer, Linda ;

Ayers, Kristin L. ;

Tan, Qihua ;

Kamatani, Yoichiro ;

Bennet, Anna M. ;

Tamm, Riin ;

Trompet, Stella ;

Guobjartsson, Daniel F. ;

Flachsbart, Friederike ;

Rose, Giuseppina ;

Viktorin, Alexander ;

Fischer, Krista ;

Nygaard, Marianne ;

Cordell, Heather J. ;

Crocco, Paolina ;

Van den Akker, Erik B. ;

Bohringer, Stefan ;

Helmer, Quinta ;

Nelson, Christopher P. ;

Saunders, Gary I. ;

Alver, Maris ;

Andersen-Ranberg, Karen ;

Breen, Marie E. ;

van der Breggen, Ruud ;

Caliebe, Amke ;

Capri, Miriam ;

Cevenini, Elisa ;

Collerton, Joanna C. ;

Dato, Serena ;

Davies, Karen ;

Ford, Ian ;

Gampe, Jutta ;

Garagnani, Paolo ;

de Geus, Eco J. C. ;

Harrow, Jennifer ;

van Heemst, Diana ;

Heijmans, Bastiaan T. ;

Heinsen, Femke-Anouska ;

Hottenga, Jouke-Jan ;

Hofman, Albert ;

Jeune, Bernard ;

Jonsson, Palmi V. ;

Lathrop, Mark ;

Lechner, Doris ;

Martin-Ruiz, Carmen ;

Mcnerlan, Susan E. ;

Mihailov, Evelin .

HUMAN MOLECULAR GENETICS, 2014, 23 (16) :4420-4432

[20] Parental Life Span and Polygenic Risk Score of Longevity Are Associated With White Matter Hyperintensities [J].

Dong, Chao ;

Thalamuthu, Anbupalam ;

Jiang, Jiyang ;

Mather, Karen A. ;

Brodaty, Henry ;

Sachdev, Perminder S. ;

Wen, Wei .

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES, 2022, 77 (04) :689-696

← 1 2 3 4 5 6 7 8 9 10 →