Polysaccharides from small black soybean alleviating type 2 diabetes via modulation of gut microbiota and serum metabolism

被引：37

作者：

Bai, Zhouya ^{[1
,2
]}

Huang, Xiaojun ^{[1
]}

Wu, Guangjie ^{[1
]}

Zhang, Yanli ^{[1
]}

Xu, Hedi ^{[1
]}

Chen, Yang ^{[1
]}

Yang, Huayu ^{[1
]}

Nie, Shaoping ^{[1
]}

机构：

[1] Nanchang Univ, State Key Lab Food Sci & Technol, Key Lab Bioact Polysaccharides Jiangxi Prov, China Canada Joint Lab Food Sci & Technol Nanchang, 235 Nanjing East Rd, Nanchang 330047, Peoples R China

[2] Henan Univ Sci & Technol, Coll Food & Bioengn, Luoyang 471023, Henan, Peoples R China

来源：

FOOD HYDROCOLLOIDS | 2023年 / 141卷

基金：

中国国家自然科学基金;

关键词：

Polysaccharides from small black soybean; Type; 2; diabetes; Antidiabetic effects; Gut microbiota; Serum metabolism; MARINE POLYSACCHARIDES; BILE-ACID; ASSOCIATION; MARKERS; OBESITY; FERMENTATION; METABOLOMICS; OSCILLOSPIRA; BACTERIA; RISK;

D O I：

10.1016/j.foodhyd.2023.108670

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Type 2 diabetes (T2DM) is a complex metabolic disorder associated with chronic high blood sugar and insulin resistance. Small black soybean, as a medicinal soybean, is used for tonifying kidney and spleen in traditional Chinese medicine. We performed the antidiabtic effect and mechanism of crude polysaccharides extracted from small black soybean (SB) by gut microbiota and metabolic modulation in STZ-induced diabetic rats. It is found that SB improved symptoms of hyperglycemia and hyperlipidemia and regulated linoleic acid metabolism. In addition, the relative abundance of Ruminococcus, Oscillospira, Dorea and Mucispirillum were modified by the middle dose of SB and these bacterial genera showed strong association with 6 vital metabolites and 10 risk indicators of T2DM. Additionally, it is further showed that 400 mg/kg pure polysaccharides exhibited more favorable antidiabetic activity than crude polysaccharides, which suggest that the antidiabetic effect of small black bean polysaccharides attributes to the pure polysaccharides.

引用

页数：12

共 66 条

[1] Circulating Linoleic Acid is Associated with Improved Glucose Tolerance in Women after Gestational Diabetes [J].