Steroids from Atactodea striata and Their Cytotoxic Activity against MCF-7 Breast Cancer Cell Lines

被引：0

作者：

Hadrian, Evan ^{[1
]}

Sari, Aprilia Permata ^{[1
]}

Mayanti, Tri ^{[1
]}

Harneti, Desi ^{[1
]}

Maharani, Rani ^{[1
]}

Darwati, Darwati ^{[1
]}

Farabi, Kindi ^{[1
]}

Supratman, Unang ^{[1
,2
]}

Waranmaselembun, Celcius ^{[3
]}

Salam, Supriatno ^{[4
]}

Fajriah, Sofa ^{[5
]}

Azmi, Muhamad Nurul ^{[6
]}

机构：

[1] Univ Padjadjaran, Fac Math & Nat Sci, Dept Chem, Jl Raya Bandung Sumedang Km 21,Jatinangor, Sumedang 45363, Indonesia

[2] Univ Padjadjaran, Cent Lab, Jl Raya Bandung-Sumedang Km 21,Jatinangor, Sumedang 45363, Indonesia

[3] State Fisheries Polytech Tual, Dept Fisheries Biotechnol, Southeast Maluku, Tual 97613, Indonesia

[4] Univ Mulawarman, Fac Pharm, Samarinda 75123, East Kalimantan, Indonesia

[5] Res Ctr Raw Mat Med & Tradit Med, Natl Res & Innovat Agcy BRIN, Tangerang Selatan 15314, Banten, Indonesia

[6] Univ Sains Malaysia, Sch Chem Sci, George Town 11800, Malaysia

来源：

INDONESIAN JOURNAL OF CHEMISTRY | 2023年 / 23卷 / 01期

关键词：

Atactodea striata; cytotoxic activity; MCF-7; steroids; CHEMICAL-CONSTITUENTS; MARINE;

D O I：

10.22146/ijc.76438

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Marine environment is known as a source of potential steroids with multiple biological activities, one of which is an anticancer agent. Atactodea striata are one of the seashells distributed in Indonesia located in the Kei Islands, Southeast Maluku. During the course of our continuing search for biologically active substances from Indonesia seashells, seven steroids have been isolated from the n-hexane fraction of A. striata and they were identified as 713-hydroxy-sitosterol (1), campesterol (2), 13-sitosterol (3), cholesterol (4), 5 alpha,8 alpha-epidioxycholest-6-en-3-13-ol (5), 7-keto-cholesterol (6), and 7 alpha-hydroxy-cholesterol (7). The structure was identified by spectroscopic methods including 2D NMR techniques, FTIR, HRTOFMS, and chemical shift comparison with previously reported spectral data. Compounds 1-7 were evaluated for their cytotoxic effects against MCF-7 breast cancer cells and showed weak or no anticancer activity.

引用

页码：200 / 209

页数：10

共 22 条

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