Selective monitoring and treatment of neuroblastoma cells with hydrogen sulfide activatable phototheranostic agent

被引：12

作者：

Dirak, Musa ^{[1
]}

Kepil, Dilay ^{[2
]}

Almammadov, Toghrul ^{[1
]}

Elmazoglu, Zubeyir ^{[3
]}

Cetin, Sultan ^{[1
]}

Ozogul, Naz ^{[2
]}

Gunbas, Gorkem ^{[2
]}

Kolemen, Safacan ^{[1
,4
,5
]}

机构：

[1] Koc Univ, Dept Chem, TR-34450 Istanbul, Turkiye

[2] Middle East Tech Univ METU, Dept Chem, TR-06800 Ankara, Turkiye

[3] Ankara Medipol Univ, Fac Pharm, Dept Pharmacol, Ankara, Turkiye

[4] Koc Univ, Res Ctr Translat Med KUTTAM, TR-34450 Istanbul, Turkiye

[5] Koc Univ, Surface Sci & Technol Ctr KUYTAM, TR-34450 Istanbul, Turkiye

来源：

DYES AND PIGMENTS | 2023年 / 210卷

关键词：

PHOTODYNAMIC THERAPY; DRUG-RESISTANCE; CANCER; LINES; MITOCHONDRIA; FLUORESCENCE; OXYGEN; PROBE;

D O I：

10.1016/j.dyepig.2022.111011

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Activity-based photosensitizers (aPSs) are highly attractive as they offer improved selectivity and better therapeutic outcome in the scope of photodynamic therapy (PDT). Here, a hydrogen sulfide (H2S) responsive iodinated resorufin-based PS (RHS) was developed to treat neuroblastoma cancer cells selectively. RHS was shown to be a phototheranostic agent as it turned on its fluorescence signal and singlet oxygen (O-1(2)) generation capability after reacting with H2S. RHS exhibited remarkable sensitivity towards H2S and proved to be highly cytotoxic in H2S rich SH-SY5Y human neuroblastoma cells upon light irradiation. In contrast, no photocytotoxicity was observed in H2S deficient nonmalignant fibroblast L929 cells. RHS marks the first example of a resorufin-based H2S activatable photo-theranostic agent, which paves the way for effective treatment of neuroblastoma through PDT modality.

引用

页数：9

共 54 条

[1] Locked and Loaded: ?-Galactosidase Activated Photodynamic Therapy Agent Enables Selective Imaging and Targeted Treatment of Glioblastoma Multiforme Cancer Cells [J].