Cytotoxic ent-abietane diterpenoids from the leaves of Croton lachnocarpus Benth.

被引：2
作者：
Wang, Wei [1 ]
Zhang, Xiao-Jie [2 ]
机构：
[1] Naval Med Ctr PLA, Dept Pharm, Shanghai 200052, Peoples R China
[2] Dept Purchasing, Unit PLA 32707, Beijing 100071, Peoples R China
来源：
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH | 2023年 / 25卷 / 04期
关键词：
Croton lachnocarpus; Euphorbiaceae; ent-abietane diterpenoids; cytotoxic activity; CLERODANE; ROOTS;
D O I：
10.1080/10286020.2022.2090346
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
A phytochemical investigation on the 90% ethanol extract of the leaves of Croton lachnocarpus Benth. led to three new ent-abietane diterpenoids, 7 beta,15-dihydroxy-ent-abieta-8,11,13-trien-3-one (1), 2 beta,15-dihydroxy-ent-abieta-8,11,13-triene (2), and 7 beta,13 alpha,15-trihydroxy-ent-abieta-8(14)-en-3-one (3). Structural elucidation of all the compounds were performed by spectral methods such as 1 D and 2 D (H-1-H-1 COSY, HMQC, NOESY and HMBC) NMR spectroscopy, in addition to electronic circular dichroism (ECD) spectra. The isolated compounds were tested in vitro for cytotoxic activity against 6 tumor cell lines. As a result, compound 3 exhibited some cytotoxicities against all the tested tumor cell lines with IC50 value less than 30 mu M.
引用
收藏
页码：309 / 315
页数：7
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