Granzyme B: A novel therapeutic target for treatment of atopic dermatitis

被引：4
|
作者：
Zhang, Qian [1 ]
Wang, Qian [1 ]
Zhang, Li-Xia [2 ,3 ]
机构：
[1] Chengdu Univ Tradit Chinese Med, Sch Med & Life Sci, Chengdu, Peoples R China
[2] Univ Elect Sci & Technol China, Sichuan Prov Peoples Hosp, Dept Dermatol & Venerol, Chengdu, Peoples R China
[3] 32, 1st Ring Rd, Chengdu, Sichuan, Peoples R China
来源：
INDIAN JOURNAL OF DERMATOLOGY VENEREOLOGY & LEPROLOGY | 2023年 / 89卷 / 02期
关键词：
Granzyme B; atopic dermatitis; pathogenesis; treatment; EXTRACELLULAR-MATRIX; SKIN INFLAMMATION; GROWTH-FACTOR; PERFORIN; BARRIER;
D O I：
10.25259/IJDVL_260_2022
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
Granzyme B is a serine protease that can play multiple roles in intracellular and extracellular perforin-dependent or non-perforin-dependent mechanisms. Granzyme B has been found to be an important factor involved in the pathogenesis of atopic dermatitis and is increased in both skin lesions and peripheral blood of atopic dermatitis patients. In this article, we review the correlation between granzyme B and atopic dermatitis to provide a novel therapeutic targeting option for clinical treatment of the latter.
引用
收藏
页码：166 / 169
页数：4
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