Anticancer Drug-Loading Capacity of Green Synthesized Porous Magnetic Iron Nanocarrier and Cytotoxic Effects Against Human Cancer Cell Line

被引：26

作者：

Ansari, Mohammad Javed ^{[1
]}

Jasim, Saade Abdalkareem ^{[2
]}

Taban, Talib Zeedan ^{[3
]}

Bokov, Dmitry Olegovich ^{[4
,5
]}

Shalaby, Mohammed Nader ^{[6
]}

Al-Gazally, Moaed E. ^{[7
]}

Kzar, Hamzah H. ^{[8
]}

Qasim, Maytham T. ^{[9
,10
]}

Mustafa, Yasser Fakri ^{[11
]}

Khatami, M. ^{[12
]}

机构：

[1] Prince Sattam Bin Abdulaziz Univ, Coll Pharm, Dept Pharmaceut, Al Kharj, Saudi Arabia

[2] Al Maarif Univ, Coll Med Lab Tech, Dept Al Anbar Ramadi, Ramadi, Iraq

[3] Kut Univ Coll, Laser & Optoelect Engn Dept, Kut 52001, Wasit, Iraq

[4] Sechenov First Moscow State Med Univ, Inst Pharm, 8 Trubetskaya St,Bldg 2, Moscow 119991, Russia

[5] Fed Res Ctr Nutr Biotechnol & Food Safety, Lab Food Chem, 2-14 Ustyinsky Pr, Moscow 109240, Russia

[6] Suez Canal Univ, Fac Phys Educ, Biol Sci & Sports Hlth Dept, Dar El Salam, Egypt

[7] Univ Al Ameed, Coll Med, Karbala, Iraq

[8] Al Qasim Green Univ, Coll Vet Med, Dept Chem, Al Qasim, Iraq

[9] Directorate Thi Qar Educ, Minist Educ, Thi Qar 64001, Iraq

[10] Al Ayen Univ, Coll Hlth & Med Technololgy, Dept Anesthesia, Thi Qar, Iraq

[11] Univ Mosul, Coll Pharm, Dept Pharmaceut Chem, Mosul 41001, Iraq

[12] Environm Res Ctr, Dept Environm Kerman, Kerman, Iran

来源：

JOURNAL OF CLUSTER SCIENCE | 2023年 / 34卷 / 01期

关键词：

Cytotoxicity; Porous alpha-Fe2O3 nanoparticles; Nanotechnology; Cancer therapy; NANOPARTICLES; DOXORUBICIN; HEMATITE; ANTIOXIDANT; PROPERTY; REMOVAL; DESIGN;

D O I：

10.1007/s10876-022-02235-4

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Porous hematite alpha-Fe2O3 nanoparticles (NPs) were synthesized using plant extract. The physicochemical characteristics of resulting porous particles were determined using X-ray diffraction (XRD), Scanning Electron Microscopy (SEM), energy dispersive X-ray (EDS), High-Resolution Transmission Electron Microscopy (HR-TEM), vibrating sample magnetometer (VSM) and N-2 adsorption-desorption isotherms (BET) analyses. The cytotoxicity of porous magnetic alpha-Fe2O3 (PMA) NPs, free anticancer drug, and anticancer drug-coated PMA NPs was evaluated against melanoma cell line (A375) and normal human cells using MTT and LDH leakage assays. BET results confirmed the presence of porous particles with the mean pore diameter of 18 nm. Porous NPs have spherical surface morphology and rhombohedral crystal structures. It was revealed that both free anticancer drug and anticancer drug-coated PMA NPs could inhibit the cell growth in a concentration-dependent manner. However, anticancer drug-loaded PMA NPs had better cytotoxic effects against melanoma cell line, evidenced via MTT and LDH leakage assays. Additionally, anticancer drug-loaded PMA NPs induced morphological alterations compatible with the occurrence of apoptotic cell death.

引用

页码：467 / 477

页数：11

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