The Function and Regulation of Platelet P2Y12 Receptor

被引：24

作者：

Li, Xiaohua ^{[1
,2
]}

Zhang, Guoxing ^{[3
]}

Cao, Xia ^{[2
]}

机构：

[1] First Hosp Jilin Univ, Dept Infect Dis, Changchun 130021, Jilin, Peoples R China

[2] Jilin Univ, Sch Pharm, Dept Pharmacol, Fujin Rd, Changchun 130021, Jilin, Peoples R China

[3] Ji Lin Tumor Hosp, ICU, Changchun, Peoples R China

来源：

CARDIOVASCULAR DRUGS AND THERAPY | 2023年 / 37卷 / 01期

关键词：

Platelet; Inflammation; Regulation; THROMBOXANE A(2) GENERATION; ACUTE CORONARY SYNDROME; SMOOTH-MUSCLE-CELLS; P2Y(12) RECEPTOR; ADENOSINE-DIPHOSPHATE; ANTIPLATELET THERAPY; ADP RECEPTORS; SYSTEMIC INFLAMMATION; SIGNAL-TRANSDUCTION; THROMBIN GENERATION;

D O I：

10.1007/s10557-021-07229-4

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

In addition to the key role in hemostasis and thrombosis, platelets have also been wildly acknowledged as immune regulatory cells and involving in the pathogenesis of inflammation-related diseases. Since purine receptor P2Y12 plays a crucial role in platelet activation, P2Y12 antagonists such as clopidogrel, prasugrel, and ticagrelor have been widely used in cardiovascular diseases worldwide in recent decades due to their potent antiplatelet and antithrombotic effects. Meanwhile, the role of P2Y12 in inflammatory diseases has also been extensively studied. Relatively, there are few studies on the regulation of P2Y12. This review first summarizes the various roles of P2Y12 in the process of platelet activation, as well as downstream effects and signaling pathways; then introduces the effects of P2Y12 in inflammatory diseases such as sepsis, atherosclerosis, cancer, autoimmune diseases, and asthma; and finally reviews the current researches on P2Y12 regulation.

引用

页码：199 / 216

页数：18

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