The Function and Regulation of Platelet P2Y12 Receptor

被引：24

作者：

Li, Xiaohua ^{[1
,2
]}

Zhang, Guoxing ^{[3
]}

Cao, Xia ^{[2
]}

机构：

[1] First Hosp Jilin Univ, Dept Infect Dis, Changchun 130021, Jilin, Peoples R China

[2] Jilin Univ, Sch Pharm, Dept Pharmacol, Fujin Rd, Changchun 130021, Jilin, Peoples R China

[3] Ji Lin Tumor Hosp, ICU, Changchun, Peoples R China

来源：

CARDIOVASCULAR DRUGS AND THERAPY | 2023年 / 37卷 / 01期

关键词：

Platelet; Inflammation; Regulation; THROMBOXANE A(2) GENERATION; ACUTE CORONARY SYNDROME; SMOOTH-MUSCLE-CELLS; P2Y(12) RECEPTOR; ADENOSINE-DIPHOSPHATE; ANTIPLATELET THERAPY; ADP RECEPTORS; SYSTEMIC INFLAMMATION; SIGNAL-TRANSDUCTION; THROMBIN GENERATION;

D O I：

10.1007/s10557-021-07229-4

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

In addition to the key role in hemostasis and thrombosis, platelets have also been wildly acknowledged as immune regulatory cells and involving in the pathogenesis of inflammation-related diseases. Since purine receptor P2Y12 plays a crucial role in platelet activation, P2Y12 antagonists such as clopidogrel, prasugrel, and ticagrelor have been widely used in cardiovascular diseases worldwide in recent decades due to their potent antiplatelet and antithrombotic effects. Meanwhile, the role of P2Y12 in inflammatory diseases has also been extensively studied. Relatively, there are few studies on the regulation of P2Y12. This review first summarizes the various roles of P2Y12 in the process of platelet activation, as well as downstream effects and signaling pathways; then introduces the effects of P2Y12 in inflammatory diseases such as sepsis, atherosclerosis, cancer, autoimmune diseases, and asthma; and finally reviews the current researches on P2Y12 regulation.

引用

页码：199 / 216

页数：18

共 185 条

[1] Clopidogrel attenuates atheroma formation and induces a stable plaque phenotype in apolipoprotein E knockout mice [J].

Afek, Arnon ;

Kogan, Evgeny ;

Maysel-Auslender, Sofia ;

Mor, Adi ;

Regev, Ehud ;

Rubinstein, Ardon ;

Keren, Gad ;

George, Jacob .

MICROVASCULAR RESEARCH, 2009, 77 (03) :364-369

[2] P2Y12 antagonism results in altered interactions between platelets and regulatory T cells during sepsis [J].

Albayati, Samara ;

Vemulapalli, Harika ;

Tsygankov, Alexander Y. ;

Liverani, Elisabetta .

JOURNAL OF LEUKOCYTE BIOLOGY, 2021, 110 (01) :141-153

[3] Inhibition of Platelets by Clopidogrel Suppressed Ang II-Induced Vascular Inflammation, Oxidative Stress, and Remodeling [J].

An, Xiangbo ;

Jiang, Guinan ;

Cheng, Cheng ;

Lv, Zhengshuai ;

Liu, Yang ;

Wang, Feng .

JOURNAL OF THE AMERICAN HEART ASSOCIATION, 2018, 7 (21)

[4] ADP-Mediated Upregulation of Expression of CD62P on Human Platelets Is Critically Dependent on Co-Activation of P2Y1 and P2Y12 Receptors [J].

Anderson, Ronald ;

Theron, Annette J. ;

Steel, Helen C. ;

Nel, Jan G. ;

Tintinger, Gregory R. .

PHARMACEUTICALS, 2020, 13 (12) :1-15

[5] Sepsis: The Involvement of Platelets and the Current Treatments [J].

Antunes Naime, Ana Carolina ;

Frade Ganaes, Jessica Oliveira ;

Lopes-Pires, Maria Elisa .

CURRENT MOLECULAR PHARMACOLOGY, 2018, 11 (04) :261-269

[6] Characterization of the Adenosine Pharmacology of Ticagrelor Reveals Therapeutically Relevant Inhibition of Equilibrative Nucleoside Transporter 1 [J].

Armstrong, Duncan ;

Summers, Claire ;

Ewart, Lorna ;

Nylander, Sven ;

Sidaway, James E. ;

van Giezen, J. J. J. .

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS, 2014, 19 (02) :209-219

[7] Platelets in Sepsis: An Update on Experimental Models and Clinical Data [J].

Assinger, Alice ;

Schrottmaier, Waltraud C. ;

Salzmann, Manuel ;

Rayes, Julie .

FRONTIERS IN IMMUNOLOGY, 2019, 10

[8] The vasodilator-stimulated phosphoprotein (VASP) is involved in cGMP- and cAMP-mediated inhibition of agonist-induced platelet aggregation, but is dispensable for smooth muscle function [J].

Aszódi, A ;

Pfeifer, A ;

Ahmad, M ;

Glauner, M ;

Zhou, XH ;

Ny, L ;

Andersson, KE ;

Kehrel, B ;

Offermanns, S ;

Fässler, R .

EMBO JOURNAL, 1999, 18 (01) :37-48

[9] Platelets Mediate Oxidized Low-Density Lipoprotein-Induced Monocyte Extravasation and Foam Cell Formation [J].

Badrnya, Sigrun ;

Schrottmaier, Waltraud C. ;

Kral, Julia B. ;

Yaiw, Koon-Chu ;

Volf, Ivo ;

Schabbauer, Gernot ;

Soderberg-Naucler, Cecilia ;

Assinger, Alice .

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2014, 34 (03) :571-580

[10] The effect of P2Y-mediated platelet activation on the release of VEGF and endostatin from platelets [J].

Bambace, Nadia M. ;

Levis, Jamie E. ;

Holmes, Chris E. .

PLATELETS, 2010, 21 (02) :85-93

← 1 2 3 4 5 6 7 8 9 10 →