Regulation of mTORC1 by the Rag GTPases

被引：12
|
作者：
Lama-Sherpa, Tshering D. [1 ,2 ,3 ]
Jeong, Mi-Hyeon [1 ,2 ,3 ]
Jewell, Jenna L. [1 ,2 ,3 ]
机构：
[1] Univ Texas Southwestern Med Ctr, Dept Mol Biol, Dallas, TX 75390 USA
[2] Univ Texas Southwestern Med Ctr, Harold C Simmons Comprehens Canc Ctr, Dallas, TX 75390 USA
[3] Univ Texas Southwestern Med Ctr, Hamon Ctr Regenerat Sci & Med, Dallas, TX 75390 USA
来源：
BIOCHEMICAL SOCIETY TRANSACTIONS | 2023年 / 51卷 / 02期
基金：
美国国家卫生研究院;
关键词：
GTP-BINDING PROTEINS; AMINO-ACID LEVELS; TRANSPORTER SLC38A9; CRYSTAL-STRUCTURE; TUMOR-SUPPRESSOR; LEUCINE SENSOR; GAP ACTIVITY; COMPLEX; PATHWAY; RAPTOR;
D O I：
10.1042/BST20210038
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The Rag GTPases are an evolutionarily conserved family that play a crucial role in amino acid sensing by the mammalian target of rapamycin complex 1 (mTORC1). mTORC1 is often referred to as the master regulator of cell growth. mTORC1 hyperactivation is observed in multiple diseases such as cancer, obesity, metabolic disorders, and neuro-degeneration. The Rag GTPases sense amino acid levels and form heterodimers, where RagA or RagB binds to RagC or RagD, to recruit mTORC1 to the lysosome where it becomes activated. Here, we review amino acid signaling to mTORC1 through the Rag GTPases.
引用
收藏
页码：655 / 664
页数：10
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