Reproducibility of T1p and T2 quantification in a multi-vendor multi-site study

Objective: To evaluate the multi-vendor multi-site reproducibility of two-dimensional (2D) multi-echo spin-echo (MESE) T2 mapping (product sequences); and to evaluate the longitudinal reproducibility of three-dimensional (3D) magnetization-prepared angle-modulated partitioned k-space spoiled gradient echo snapshots (MAPSS) T1p and T2 mapping (research sequences), and 2D MESE T2 mapping, separated by 6 months, in a multi-vendor multi-site setting. Methods: Phantoms and volunteers (n 1/4 5 from each site, n 1/4 20 in total) were scanned on four 3 T magnetic resonance (MR) systems from four sites and three vendors (Siemens, General Electric, and Phillips). Two traveling volunteers (3 knees) scanned at all 4 sites at baseline and 6-month follow-up. Data was transferred to one site for centralized processing. Coefficients of variation (CVs) were calculated to evaluate reproducibility. Results: For baseline 2D MESE T2 measures, average CV were 0.37-2.45% (intra-site) and 5.96% (intersite) for phantoms, and 3.15-8.49% (intra-site) and 14.16% (inter-site) for volunteers. For longitudinal phantom data, intra-site CVs were 1.42-3.48% for 3D MAPSS T1p, 1.77-3.56% for 3D MAPSS T2, and 1.02 -2.54% for 2D MESE T2. For the longitudinal volunteer data, the intra-site CVs were 2.60-4.86% for 3D MAPSS T1p, 3.33-7.25% for 3D MAPSS T2, and 3.11-8.77% for 2D MESE T2. Conclusion: This study demonstrated excellent intra-site reproducibility of 2D MESE T2 imaging, while its inter-site variation was slightly higher than 3D MAPSS T2 imaging (10.06% as previously reported). This study also showed excellent reproducibility of longitudinal T1p and T2 cartilage quantification, in a multivendor multi-site setting for both product 2D MESE T2 and 3D MAPSS T1p/T2 research sequences. (c) 2022 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.