The U-Shaped association between age and distant metastasis in patients with papillary thyroid carcinoma

被引：1

作者：

Huang, Hui ^{[1
]}

Ni, Song ^{[1
]}

Liu, Wensheng ^{[1
]}

Wang, Xiaolei ^{[1
]}

Liu, Shaoyan ^{[1
]}

机构：

[1] Chinese Acad Med Sci & Peking Union Med Coll, Dept Head & Neck Surg Oncol, Natl Canc Ctr, Natl Clin Res Ctr Canc,Canc Hosp, 17 Panjiayuan Nanli, Beijing, Peoples R China

来源：

ENDOCRINE | 2024年 / 85卷 / 01期

关键词：

Thyroid cancer; Papillary carcinoma; Distant metastasis; Age; Risk factor; CANCER; SYMPORTER; DISEASE; RISK;

D O I：

10.1007/s12020-023-03676-1

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Purpose To investigate the association between age distribution and synchronous distant metastasis of papillary thyroid carcinoma.Method Patients with PTC who were treated from January 2013 to December 2018 at a single institute in a cancer referral center in China were retrospectively reviewed. A logistic regression model with restricted cubic splines (RCS) was used to examine the association between age at diagnosis and synchronous distant metastasis.Results A total of 111 patients (0.7%) were diagnosed with distant metastasis. The logistic regression model with RCS revealed a "U-shape" association between age and distant metastasis. The RCS curve suggested a U-shaped pattern. The multivariable regression analysis showed that patients in the age groups <= 21 years (OR 2.33, 95% CI 1.09-4.68, P = 0.022) and >55 years (OR 3.32, 95% CI 1.99-5.46, P < 0.001) had a significantly higher incidence of distant metastasis than patients in the age group of 22 to 55 years.Conclusions A U-shaped association was observed between age at diagnosis and synchronous distant metastasis in papillary thyroid carcinoma patients.

引用

页码：258 / 266

页数：9

共 19 条

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