Human leukocyte immunoglobulin-like receptors in health and disease

被引:15
作者
Redondo-Garcia, Silvia [1 ]
Barritt, Christopher [1 ,2 ,3 ]
Papagregoriou, Charys [1 ,6 ]
Yeboah, Muchaala [1 ]
Frendeus, Bjorn [1 ,4 ]
Cragg, Mark S. [1 ,5 ]
Roghanian, Ali [1 ,5 ]
机构
[1] Univ Southampton, Sch Canc Sci, Antibody & Vaccine Grp, Ctr Canc Immunol,Fac Med,Southampton Gen Hosp, Southampton, England
[2] Glasgow Royal Infirm, Lister Dept Gen Surg, Glasgow, Scotland
[3] Univ Glasgow, Sch Med Dent & Nursing, Glasgow, Scotland
[4] BioInvent Int AB, Lund, Sweden
[5] Univ Southampton, Inst Life Sci, Southampton, England
[6] Ctr Study Haematol & Other Malignancies, Nicosia, Cyprus
来源
FRONTIERS IN IMMUNOLOGY | 2023年 / 14卷
基金
英国医学研究理事会; 英国生物技术与生命科学研究理事会;
关键词
LILR; immune tolerance; cancer; autoimmunity; infection; immunomodulation; immunotherapy; MHC CLASS-I; SOLUBLE HLA-G; T-SUPPRESSOR-CELLS; ANTIGEN-PRESENTING CELLS; TOLEROGENIC ENDOTHELIAL-CELLS; PLASMACYTOID DENDRITIC CELLS; SYSTEMIC-LUPUS-ERYTHEMATOSUS; ACUTE MYELOID-LEUKEMIA; NATURAL-KILLER-CELLS; VERSUS-HOST-DISEASE;
D O I
10.3389/fimmu.2023.1282874
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Human leukocyte immunoglobulin (Ig)-like receptors (LILR) are a family of 11 innate immunomodulatory receptors, primarily expressed on lymphoid and myeloid cells. LILRs are either activating (LILRA) or inhibitory (LILRB) depending on their associated signalling domains (D). With the exception of the soluble LILRA3, LILRAs mediate immune activation, while LILRB1-5 primarily inhibit immune responses and mediate tolerance. Abnormal expression and function of LILRs is associated with a range of pathologies, including immune insufficiency (infection and malignancy) and overt immune responses (autoimmunity and alloresponses), suggesting LILRs may be excellent candidates for targeted immunotherapies. This review will discuss the biology and clinical relevance of this extensive family of immune receptors and will summarise the recent developments in targeting LILRs in disease settings, such as cancer, with an update on the clinical trials investigating the therapeutic targeting of these receptors.
引用
收藏
页数:29
相关论文
共 316 条
  • [1] Leukocyte Immunoglobulin-Like Receptors in Regulating the Immune Response in Infectious Diseases: A Window of Opportunity to Pathogen Persistence and a Sound Target in Therapeutics
    Abdallah, Florence
    Coindre, Sixtine
    Gardet, Margaux
    Meurisse, Florian
    Naji, Abderrahim
    Suganuma, Narufumi
    Abi-Rached, Laurent
    Lambotte, Olivier
    Favier, Benoit
    [J]. FRONTIERS IN IMMUNOLOGY, 2021, 12
  • [2] Role of HLA-G in tumor escape through expansion of myeloid-derived suppressor cells and cytokinic balance in favor of Th2 versus Th1/Th17
    Agaugue, Sophie
    Carosella, Edgardo D.
    Rouas-Freiss, Nathalie
    [J]. BLOOD, 2011, 117 (26) : 7021 - 7031
  • [3] Antigen Presentation in Transplantation
    Alegre, Maria-Luisa
    Lakkis, Fadi G.
    Morelli, Adrian E.
    [J]. TRENDS IN IMMUNOLOGY, 2016, 37 (12) : 831 - 843
  • [4] Soluble LILRA3 promotes neurite outgrowth and synapses formation through a high-affinity interaction with Nogo 66
    An, Hongyan
    Brettle, Merryn
    Lee, Terry
    Heng, Benjamin
    Lim, Chai K.
    Guillemin, Gilles J.
    Lord, Megan S.
    Klotzsch, Enrico
    Geczy, Carolyn L.
    Bryant, Katherine
    Fath, Thomas
    Tedla, Nicodemus
    [J]. JOURNAL OF CELL SCIENCE, 2016, 129 (06) : 1198 - 1209
  • [5] Soluble LILRA3, a Potential Natural Antiinflammatory Protein, Is Increased in Patients with Rheumatoid Arthritis and Is Tightly Regulated by Interleukin 10, Tumor Necrosis Factor-α, and Interferon-γ
    An, Hongyan
    Chandra, Vasudha
    Piraino, Barbara
    Borges, Luis
    Geczy, Carolyn
    McNeil, H. Patrick
    Bryant, Katherine
    Tedla, Nicodemus
    [J]. JOURNAL OF RHEUMATOLOGY, 2010, 37 (08) : 1596 - 1606
  • [6] LILRB4-targeting Antibody-Drug Conjugates for the Treatment of Acute Myeloid Leukemia
    Anami, Yasuaki
    Deng, Mi
    Gui, Xun
    Yamaguchi, Aiko
    Yamazaki, Chisato M.
    Zhang, Ningyan
    Zhang, Chengcheng
    An, Zhiqiang
    Tsuchikama, Kyoji
    [J]. MOLECULAR CANCER THERAPEUTICS, 2020, 19 (11) : 2330 - 2339
  • [7] Regulation of T-cell immunity by leucocyte immunoglobulin-like receptors: innate immune receptors for self on antigen-presenting cells
    Anderson, Katie J.
    Allen, Rachel L.
    [J]. IMMUNOLOGY, 2009, 127 (01) : 8 - 17
  • [8] Coordinated expression of ig-like inhibitory MHC class I receptors and acquisition of cytotoxic function in human CD8+ T cells
    Anfossi, N
    Doisne, JM
    Peyrat, MA
    Ugolini, S
    Bonnaud, O
    Bossy, D
    Pitard, V
    Merville, P
    Moreau, JF
    Delfraissy, JF
    Dechanet-Merville, J
    Bonneville, M
    Venet, A
    Vivier, E
    [J]. JOURNAL OF IMMUNOLOGY, 2004, 173 (12) : 7223 - 7229
  • [9] A homodimeric complex of HLA-G on normal trophoblast cells modulates antigen-presenting cells via LILRB1
    Apps, Richard
    Gardner, Lucy
    Sharkey, Andrew M.
    Holmes, Nick
    Moffett, Ashley
    [J]. EUROPEAN JOURNAL OF IMMUNOLOGY, 2007, 37 (07) : 1924 - 1937
  • [10] S100A9 protein is a novel ligand for the CD85j receptor and its interaction is implicated in the control of HIV-1 replication by NK cells
    Arnold, Vincent
    Cummings, Jean-Saville
    Moreno-Nieves, Uriel Y.
    Didier, Celine
    Gilbert, Adrien
    Barre-Sinoussi, Francoise
    Scott-Algara, Daniel
    [J]. RETROVIROLOGY, 2013, 10