Sulfated polysaccharides in sea cucumbers and their biological properties: A review

被引：35
作者：
Hossain, Abul [1 ]
Dave, Deepika [1 ,2 ]
Shahidi, Fereidoon [1 ]
机构：
[1] Mem Univ Newfoundland, Dept Biochem, St John, NF A1C 5S7, Canada
[2] Mem Univ Newfoundland, Fisheries & Marine Inst, Ctr Aquaculture & Seafood Dev, Marine Bioproc Facil, St John, NF A1C 5R3, Canada
来源：
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | 2023年 / 253卷
基金：
加拿大自然科学与工程研究理事会;
关键词：
Sea cucumber; Sulfated polysaccharide; Fucosylated chondroitin sulfate; Fucan sulfates; Structure; Biological activity; FUCOSYLATED CHONDROITIN SULFATE; INTRINSIC-FACTOR XASE; STRUCTURAL-CHARACTERIZATION; ANTICOAGULANT ACTIVITIES; PEARSONOTHURIA-GRAEFFEI; ACAUDINA-MOLPADIOIDES; CUCUMARIA-FRONDOSA; PHYSICOCHEMICAL PROPERTIES; APOSTICHOPUS-JAPONICUS; PANCREATIC-ISLETS;
D O I：
10.1016/j.ijbiomac.2023.127329
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Sea cucumbers contain a wide range of biomolecules, including sulfated polysaccharides (SPs), with immense therapeutic and nutraceutical potential. SPs in sea cucumbers are mainly fucosylated chondroitin sulfate (FCS) and fucan sulfate (FS) which exhibit a series of pharmacological effects, including anticoagulant activity, in several biological systems. FCS is a structurally distinct glycosaminoglycan in the sea cucumber body wall, and its biological properties mainly depend on the degree of sulfation, position of sulfate group, molecular weight, and distribution of branches along the backbone. So far, FCS and FS have been recognized for their antithrombotic, anti-inflammatory, anticancer, antidiabetic, anti-hyperlipidemic, anti-obesity, and antioxidant potential. However, the functions of these SPs are mainly dependent on the species, origins, harvesting season, and extraction methods applied. This review focuses on the SPs of sea cucumbers and how their structural diversities affect various biological activities. In addition, the mechanism of actions of SPs, chemical structures, factors affecting their bioactivities, and their extraction methods are also discussed.
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页数：22
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