Effectiveness of BA.1-and BA.4/BA. 5-Containing Bivalent COVID-19 mRNA Vaccines Against Symptomatic SARS-CoV-2 Infection During the BA.5-Dominant Period in Japan

被引:13
作者
Arashiro, Takeshi [1 ,2 ,3 ,4 ]
Arima, Yuzo [1 ]
Kuramochi, Jin [5 ,6 ]
Muraoka, Hirokazu [7 ]
Sato, Akihiro [8 ]
Chubachi, Kumi [9 ]
Yanai, Atsushi [10 ]
Arioka, Hiroko [10 ]
Uehara, Yuki [11 ,12 ]
Ihara, Genei [13 ]
Kato, Yasuyuki [14 ]
Yanagisawa, Naoki [15 ]
Ueda, Akihiro [16 ]
Kato, Hideaki [17 ]
Oka, Hideaki [18 ]
Nishida, Yusuke [18 ]
Nidaira, Yuki [5 ]
Asami, Takahiro [19 ]
Jinta, Torahiko [20 ]
Nakamura, Akira [21 ]
Oba, Kunihiro [22 ]
Taniyama, Daisuke [23 ]
Yamamoto, Kei [18 ]
Tanaka, Katsushi [17 ]
Ueshima, Kankuro [24 ]
Fuwa, Tetsuji [24 ]
Stucky, Ashley [1 ]
Suzuki, Tadaki [2 ]
Smith, Chris [3 ]
Hibberd, Martin [3 ]
Ariyoshi, Koya [4 ]
Suzuki, Motoi [1 ]
机构
[1] Natl Inst Infect Dis, Ctr Surveillance Immunizat & Epidemiol Res, Tokyo, Japan
[2] Natl Inst Infect Dis, Dept Pathol, Tokyo, Japan
[3] London Sch Hyg & Trop Med, Fac Infect & Trop Dis, London, England
[4] Nagasaki Univ, Sch Trop Med & Global Hlth, Nagasaki, Japan
[5] Kuramochi Clin Interpk, Tochigi, Japan
[6] Tokyo Med & Dent Univ, Dept Global Hlth Promot, Tokyo, Japan
[7] Clin TAMACHI, Tokyo, Japan
[8] KARADA Internal Med Clin, Tokyo, Japan
[9] Chubachi Internal Resp Med Clin, Tokyo, Japan
[10] St Lukes Int Hosp, Dept Gen Internal Med, Tokyo, Japan
[11] St Lukes Int Hosp, Dept Clin Lab, Tokyo, Japan
[12] Fujita Hlth Univ, Sch Med, Dept Infect Dis, Aichi, Japan
[13] Machida Ekimae Naika Clin, Tokyo, Japan
[14] Int Univ Hlth, Welf Narita Hosp, Dept Infect Dis, Chiba, Japan
[15] Yanagisawa Clin, Tokyo, Japan
[16] Japanese Red Cross Med Ctr, Dept Infect Dis, Tokyo, Japan
[17] Yokohama City Univ Med, Infect Prevent & Control Dept, Yokohama, Japan
[18] Saitama Med Ctr, Dept Gen Internal Med & Infect Dis, Saitama, Japan
[19] Sano Kosei Gen Hosp, Dept Internal Med, Tochigi, Japan
[20] St Lukes Int Hosp, Dept Pulm Med, Tokyo, Japan
[21] Asahi Gen Hosp, Dept Internal Med, Chiba, Japan
[22] Showa Gen Hosp, Dept Pediat, Tokyo, Japan
[23] Showa Gen Hosp, Dept Infect Dis, Tokyo, Japan
[24] NATURALI Co Ltd, Tokyo, Japan
关键词
COVID-19; SARS-CoV-2; variants; test-negative design; vaccine effectiveness;
D O I
10.1093/ofid/ofad240
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
In this multicenter, prospective, test-negative, case-control study in Japan, the effectiveness of both BA.1-containing and BA.4/BA.5-containing bivalent coronavirus disease 2019 mRNA vaccines against symptomatic infection during the BA.5-dominant period was high compared with no vaccination (65% and 76%) and moderate compared with monovalent vaccines administered over half a year earlier (46% combined). In this multi-center study in Japan, the effectiveness of both BA.1-containing and BA.4/BA.5-containing bivalent vaccines against symptomatic infection during the BA.5-dominant period was high compared to no vaccination (65%/76%) and moderate compared to monovalent vaccines >6 months before (46% combined).
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页数:6
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