Based on functional and histopathological correlations: is diffusion kurtosis imaging valuable for noninvasive assessment of renal damage in early-stage of chronic kidney disease?

被引:5
作者
Lin, Jiazhen [1 ]
Zhu, Caifeng [2 ]
Cui, Feng [3 ]
Qu, Hua [3 ]
Zhang, Yongsheng [3 ]
Le, Xianjie [3 ]
Yin, Jiazhen [2 ]
Cao, Youjun [3 ]
机构
[1] Zhejiang Chinese Med Univ, Hangzhou Hosp Tradit Chinese Med, 453 Rd Stadium, Hangzhou 310000, Zhejiang, Peoples R China
[2] Zhejiang Chinese Med Univ, Hangzhou Hosp Tradit Chinese Med, Dept Nephrol, 453 Rd Stadium, Hangzhou 310000, Zhejiang, Peoples R China
[3] Zhejiang Chinese Med Univ, Hangzhou Hosp Tradit Chinese Med, Dept Radiol, 453 Rd Stadium, Hangzhou 310000, Zhejiang, Peoples R China
关键词
Diffusion kurtosis imaging; Mean kurtosis; Mean diffusivity; Fractional anisotropy; Chronic kidney disease; Renal damage; GAUSSIAN WATER DIFFUSION; FIBROSIS; QUANTIFICATION; NEPHROPATHY; FILTRATION; MRI;
D O I
10.1007/s11255-023-03632-y
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
PurposeTo evaluate the potential of 3 T magnetic resonance diffusion kurtosis imaging (DKI) in assessing the renal damage in early-stage of chronic kidney disease (CKD) patients with normal or slightly changed functional index, using histopathology as reference standard.Methods49 CKD patients and 18 healthy volunteers were recruited in this study. CKD patients were divided into two groups based on estimated glomerular filtration rate (eGFR): Study group I (eGFR >= 90 ml/min/1.73 m(2) [n = 20]) and Study group II (eGFR < 90 ml/min/1.73 m(2) [n = 29]). DKI was performed in all participants. The DKI parameters (mean kurtosis [MK], mean diffusivity [MD], fractional anisotropy [FA]) of renal cortex and medulla were measured. The differences of parenchymal MD, MK and FA values among the different groups were compared. The correlations between DKI parameters and clinicopathological characteristics were assessed. Diagnostic performance of DKI to assess renal damage in early-stage of CKD was analyzed.ResultsThe cortex MD and MK showed significant difference among three groups (P < 0.05): trend of cortex MD: Study group II < Study group I < control group; trend of cortex MK: control group < Study group I < Study group II. The cortex MD and MK and medulla FA were correlated with eGFR and Interstitial fibrosis/Tubular atrophy score (0.3 < r < 0.5). Cortex MD and MK yielded an AUC of 0.752 for differentiating healthy volunteers from CKD patients with eGFR >= 90 ml/min/1.73 m(2).ConclusionDKI shows potential in non-invasive and multi-parameter quantitative assessment of renal damage in early-stage of CKD patients and provide additional information for changes in renal function and histopathology.
引用
收藏
页码:263 / 273
页数:11
相关论文
共 31 条
[1]   Use of intravoxel incoherent motion MRI to assess renal fibrosis in a rat model of unilateral ureteral obstruction [J].
Cai, Xiang-Ran ;
Yu, Juan ;
Zhou, Qing-Chun ;
Du, Bin ;
Feng, You-Zhen ;
Liu, Xiao-ling .
JOURNAL OF MAGNETIC RESONANCE IMAGING, 2016, 44 (03) :698-706
[2]   Characterization of clear cell renal cell carcinoma with diffusion kurtosis imaging: correlation between diffusion kurtosis parameters and tumor cellularity [J].
Dai, Yongming ;
Yao, Qiuying ;
Wu, Guangyu ;
Wu, Dongmei ;
Wu, Lianming ;
Zhu, Li ;
Xue, Rong ;
Xu, Jianrong .
NMR IN BIOMEDICINE, 2016, 29 (07) :873-881
[3]   Diffusion tensor imaging and tractography of the kidneys: assessment of chronic parenchymal diseases [J].
Gaudiano, Caterina ;
Clementi, Valeria ;
Busato, Fiorenza ;
Corcioni, Beniamino ;
Orrei, Maria Grazia ;
Ferramosca, Emiliana ;
Fabbri, Emma ;
Berardi, Paola ;
Santoro, Antonio ;
Golfieri, Rita .
EUROPEAN RADIOLOGY, 2013, 23 (06) :1678-1685
[4]  
HOSTETTER TH, 1981, AM J PHYSIOL, V241, pF85, DOI 10.1681/ASN.V1261315
[5]   COMPENSATORY RENAL HEMODYNAMIC INJURY - A FINAL COMMON PATHWAY OF RESIDUAL NEPHRON DESTRUCTION [J].
HOSTETTER, TH ;
RENNKE, HG ;
BRENNER, BM .
AMERICAN JOURNAL OF KIDNEY DISEASES, 1982, 1 (05) :310-314
[6]   MRI quantification of non-Gaussian water diffusion in normal human kidney: a diffusional kurtosis imaging study [J].
Huang, Yanqi ;
Chen, Xin ;
Zhang, Zhongping ;
Yan, Lifen ;
Pan, Dan ;
Liang, Changhong ;
Liu, Zaiyi .
NMR IN BIOMEDICINE, 2015, 28 (02) :154-161
[7]   MRI quantification of non-Gaussian water diffusion by kurtosis analysis [J].
Jensen, Jens H. ;
Helpern, Joseph A. .
NMR IN BIOMEDICINE, 2010, 23 (07) :698-710
[8]   Diffusional kurtosis imaging: The quantification of non-Gaussian water diffusion by means of magnetic resonance imaging [J].
Jensen, JH ;
Helpern, JA ;
Ramani, A ;
Lu, HZ ;
Kaczynski, K .
MAGNETIC RESONANCE IN MEDICINE, 2005, 53 (06) :1432-1440
[9]  
Katafuchi R, 1998, CLIN NEPHROL, V49, P1
[10]   Fast diffusion kurtosis imaging of fibrotic mouse kidneys [J].
Kjolby, B. F. ;
Khan, A. R. ;
Chuhutin, A. ;
Pedersen, L. ;
Jensen, J. B. ;
Jakobsen, S. ;
Zeidler, D. ;
Sangill, R. ;
Nyengaard, J. R. ;
Jespersen, S. N. ;
Hansen, B. .
NMR IN BIOMEDICINE, 2016, 29 (12) :1709-1719