Mycobacterium tuberculosis disease associates with higher HIV-1-specific antibody responses

被引：2

作者：

Adeoye, Bukola ^{[1
]}

Nakiyingi, Lydia ^{[2
]}

Moreau, Yvetane ^{[3
]}

Nankya, Ethel ^{[4
]}

Olson, Alex J. ^{[3
]}

Zhang, Mo ^{[3
]}

Jacobson, Karen R. ^{[3
]}

Gupta, Amita ^{[5
]}

Manabe, Yukari C. ^{[5
]}

Hosseinipour, Mina C. ^{[6
]}

Kumwenda, Johnstone ^{[7
]}

Sagar, Manish ^{[1
,3
]}

机构：

[1] Boston Univ, Dept Microbiol, Sch Med, Boston, MA 02118 USA

[2] Makerere Univ, Infect Dis Inst, Coll Hlth Sci, Kampala, Uganda

[3] Boston Med Ctr, Dept Med, Boston, MA 02118 USA

[4] Boston Univ, Div Computat Biomed, Sch Med, Boston, MA 02118 USA

[5] Johns Hopkins Univ, Dept Med, Sch Med, Baltimore, MD USA

[6] Univ N Carolina, Sch Med, Chapel Hill, NC USA

[7] Univ Malawi, Coll Med, Blantyre, Malawi

来源：

ISCIENCE | 2023年 / 26卷 / 05期

基金：

美国国家卫生研究院;

关键词：

IMMUNODEFICIENCY-VIRUS TYPE-1; NEUTRALIZING ANTIBODIES; HETEROLOGOUS IMMUNITY; T-CELLS; B-CELLS; HIV-1; INFECTION; VACCINE; INFLAMMATION; INDIVIDUALS;

D O I：

10.1016/j.isci.2023.106631

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Mycobacterium tuberculosis (Mtb) is the most common infection among people with HIV (PWH). Mtb disease-associated inflammation could affect HIV-directed immune responses in PWH. We show that HIV antibodies are broader and more potent in PWH in the presence as compared to the absence of Mtb disease. With co-existing Mtb disease, the virus in PWH also encounters unique antibody selection pressure. The Mtb-linked HIV antibody enhancement associates with specific mediators important for B cell and antibody development. This Mtb humoral augmentation does not occur due to cross-reactivity, a generalized in-crease in all antibodies, or differences in duration or amount of antigen exposure. We speculate that the co-localization of Mtb and HIV in lymphatic tissues leads to the emergence of potent HIV antibodies. PWH's Mtb disease status has implica-tions for the future use of HIV broadly neutralizing antibodies as prophylaxis or treatment and the induction of better humoral immunity.

引用

页数：22

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