Palladium/Rhodium/Iridium Trimetallic Octahedral Nanozymes Exhibiting Enhanced Peroxidase-like Activity for Detecting Total Antioxidant Capacity in Food

被引：25

作者：

Yang, Lin ^{[1
,2
]}

Yang, ZeHua ^{[1
,2
]}

He, Jian ^{[1
,2
]}

Cao, Qianqian ^{[1
,2
]}

Zhang, Ruilin ^{[1
,2
]}

Wang, Qiao ^{[3
]}

Chen, Zhixi ^{[4
]}

Chen, Weiwei ^{[5
]}

Wang, Weiguo ^{[1
,2
]}

机构：

[1] Univ South China, Inst Pharm & Pharmacol, Hengyang 421000, Hunan, Peoples R China

[2] Hunan Xinhexin Biol Med Co Ltd, Pharm Grad Educ Innovat Base, Hunan Prov Cooperat Innovat Ctr Mol Target New Dru, Hengyang 421000, Hunan, Peoples R China

[3] Univ South China, Affiliated Hosp 1, Dept Ultrasound Imaging, Hengyang Med Coll, Hengyang 421001, Hunan, Peoples R China

[4] Univ South China, Affiliated Hosp 1, Hengyang Med Coll, Blood Transfus Dept, Hengyang 421001, Hunan, Peoples R China

[5] Univ South China, Hengyang Med Coll, Hengyang 421000, Hunan, Peoples R China

来源：

ACS APPLIED NANO MATERIALS | 2023年 / 6卷 / 06期

关键词：

nanozyme; peroxidase-like activity; transition metal; trimetallic; subsurface; total antioxidant capacity; OXIDATIVE STRESS; MECHANISM; PLATINUM;

D O I：

10.1021/acsanm.2c05400

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

Nanozymes are widely used in detecting biomarkers. However, designing nanozymes exhibiting high peroxidase-like activity is challenging. This study aimed to synthesize two types of nanozyme (PI nanozyme), exhibiting similar morphologies and enhanced activities. The first nanozyme comprised palladium, rhodium, and iridium (PRI nanozyme), while the second nanozyme comprised palladium and iridium (PI nanozyme). The PRI nanozyme exhibited a higher peroxidase-like activity than the PI nanozyme. Rhodium in the subsurface of the PRI nanozyme can lower the hydrogen peroxide decomposition energy and increase the hydroxyl radical (center dot OH) content in a catalytic system. As a proof of concept, the PRI nanozyme was used to detect ascorbic acid, cysteine, and glutathione, with limits of detection (LODs) being 0.14, 0.18, and 0.21 mu M, respectively. Finally, the PRI nanozymebased method was applied to determine the total antioxidant capacities (TACs) of different beverages, fruits, and vegetables. Among the tested samples, Actinidia Chinensis Planch exhibited the highest TAC. This study broadens the application of multimetallic nanozymes in the field of food quality and safety.

引用

页码：4288 / 4296

页数：9

共 34 条

[1] Review on in vivo and in vitro methods evaluation of antioxidant activity [J].

Alam, Md. Nur ;

Bristi, Nusrat Jahan ;

Rafiquzzaman, Md. .

SAUDI PHARMACEUTICAL JOURNAL, 2013, 21 (02) :143-152

[2]

Antolovich M, 2002, ANALYST, V127, P183, DOI 10.1039/b009171p

[3] Spectrophotometric Determination of Phenolic Antioxidants in the Presence of Thiols and Proteins [J].

Avan, Asli Neslihan ;

Cekic, Sema Demirci ;

Uzunboy, Seda ;

Apak, Resat .

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2016, 17 (08)

[4] Total antioxidant capacity of the diet is inversely and independently related to plasma concentration of high-sensitivity C-reactive protein in adult Italian subjects [J].

Brighenti, F ;

Valtueña, S ;

Pellegrini, N ;

Ardigò, D ;

Del Rio, D ;

Salvatore, S ;

Piatti, P ;

Serafini, M ;

Zavaroni, I .

BRITISH JOURNAL OF NUTRITION, 2005, 93 (05) :619-625

[5] Oxidative stress in Alzheimer's disease [J].

Chen, Zhichun ;

Zhong, Chunjiu .

NEUROSCIENCE BULLETIN, 2014, 30 (02) :271-281

[6] Antioxidants in Foods: State of the Science Important to the Food Industry [J].

Finley, John W. ;

Kong, Ah-Ng ;

Hintze, Korry J. ;

Jeffery, Elizabeth H. ;

Ji, Li Li ;

Lei, Xin Gen .

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2011, 59 (13) :6837-6846

[7] Intrinsic peroxidase-like activity of ferromagnetic nanoparticles [J].

Gao, Lizeng ;

Zhuang, Jie ;

Nie, Leng ;

Zhang, Jinbin ;

Zhang, Yu ;

Gu, Ning ;

Wang, Taihong ;

Feng, Jing ;

Yang, Dongling ;

Perrett, Sarah ;

Yan, Xiyun .

NATURE NANOTECHNOLOGY, 2007, 2 (09) :577-583

[8] Oxidase-like Fe-Mn bimetallic nanozymes for colorimetric detection of ascorbic acid in kiwi fruit [J].

Han, Yaru ;

Luo, Linpin ;

Zhang, Liang ;

Kang, Yi ;

Sun, Hao ;

Dan, Jie ;

Sun, Jing ;

Zhang, Wentao ;

Yue, Tianli ;

Wang, Jianlong .

LWT-FOOD SCIENCE AND TECHNOLOGY, 2022, 154

[9] Nanozyme: new horizons for responsive biomedical applications [J].

Jiang, Dawei ;

Ni, Dalong ;

Rosenkrans, Zachary T. ;

Huang, Peng ;

Yan, Xiyun ;

Cai, Weibo .

CHEMICAL SOCIETY REVIEWS, 2019, 48 (14) :3683-3704

[10] Maximizing the peroxidase-like activity of Pd@PtxRu4-x nanocubes by precisely controlling the shell thickness and their application in colorimetric biosensors [J].

Jiang, Yiming ;

Zhu, Jiawei ;

Li, Li ;

Gao, Yahui ;

Leng, Juncai ;

Yan, Jiai ;

Liu, Shuoming ;

Zhang, Feng ;

Liu, Han ;

Zhu, Chenlu ;

Guo, Lichun ;

Xie, Haijiao ;

Zhao, Wei .

NANOSCALE, 2022, 14 (20) :7596-7606

← 1 2 3 4 →