Anti-Hyperuricemic Effect of Anserine Based on the Gut-Kidney Axis: Integrated Analysis of Metagenomics and Metabolomics

被引：15

作者：

Halimulati, Mairepaiti ^{[1
]}

Wang, Ruoyu ^{[1
]}

Aihemaitijiang, Sumiya ^{[1
]}

Huang, Xiaojie ^{[1
]}

Ye, Chen ^{[1
]}

Zhang, Zongfeng ^{[1
]}

Li, Lutong ^{[1
]}

Zhu, Wenli ^{[1
,2
]}

Zhang, Zhaofeng ^{[1
,2
]}

He, Lixia ^{[3
]}

机构：

[1] Peking Univ, Sch Publ Hlth, Dept Nutr & Food Hyg, Beijing 100871, Peoples R China

[2] Beijings Key Lab Food Safety Toxicol Res & Evaluat, Beijing 100871, Peoples R China

[3] Harvard Med Sch, Brigham & Womens Hosp, Dana Farber Canc Inst, Div Mol & Cellular Oncol, Boston, MA 02115 USA

来源：

NUTRIENTS | 2023年 / 15卷 / 04期

基金：

英国科研创新办公室;

关键词：

hyperuricemia; anserine; metagenomics; urine metabolomics; integrated analysis; gut-kidney axis; URIC-ACID; DIET; PHYSIOLOGY; DISEASE; INJURY;

D O I：

10.3390/nu15040969

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Nowadays, developing effective intervention substances for hyperuricemia has become a public health issue. Herein, the therapeutic ability of anserine, a bioactive peptide, was validated through a comprehensive multiomics analysis of a rat model of hyperuricemia. Anserine was observed to improve liver and kidney function and modulate urate-related transporter expressions in the kidneys. Urine metabolomics showed that 15 and 9 metabolites were significantly increased and decreased, respectively, in hyperuricemic rats after the anserine intervention. Key metabolites such as fructose, xylose, methionine, erythronic acid, glucaric acid, pipecolic acid and trans-ferulic acid were associated with ameliorating kidney injury. Additionally, anserine regularly changed the gut microbiota, thereby ameliorating purine metabolism abnormalities and alleviating inflammatory responses. The integrated multiomics analysis indicated that Saccharomyces, Parasutterella excrementihominis and Emergencia timonensis were strongly associated with key differential metabolites. Therefore, we propose that anserine improved hyperuricemia via the gut-kidney axis, highlighting its potential in preventing and treating hyperuricemia.

引用

页数：18

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