Non-steroidal anti-inflammatory drugs (NSAIDs): A current insight into its molecular mechanism eliciting organ toxicities

被引：67

作者：

Panchal, Nagesh Kishan ^{[1
]}

Sabina, Evan Prince ^{[1
,2
]}

机构：

[1] Vellore Inst Technol, Sch Biosci, Dept Biotechnol & Technol, Vellore, India

[2] Vellore Inst Technol, Sch Biosci & Technol, Dept Biotechnol, Vellore 632014, India

来源：

FOOD AND CHEMICAL TOXICOLOGY | 2023年 / 172卷

关键词：

Non-steroidal anti-inflammatory drugs; Cyclooxygenases; Hepatotoxicity; Gastrointestinal toxicity; Cardiovascular toxicity; Renal toxicity; KAPPA-B ACTIVATION; MYOCARDIAL-INFARCTION; RISK; ASPIRIN; INJURY; DICLOFENAC; IBUPROFEN; CYCLOOXYGENASE-2; DIPHENYLAMINE; INDOMETHACIN;

D O I：

10.1016/j.fct.2022.113598

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

Non-steroidal anti-inflammatory drugs (NSAIDs) are a class of medications that are routinely been used across the world. Their analgesic, anti-inflammatory, and antipyretic effects have all been well-documented. Moreover, they are been deliberated to have a protective role against various critical diseases such as cancer and cardio-vascular diseases. However, the data presented by numerous studies in past have signified the adverse effects of NSAIDs due to overdosing on various systems such as cardiovascular, gastrointestinal, hepatic, renal, neural, etc. Despite substantial studies representing the mechanism behind the clinical risk of NSAIDs, there are very few reviews that have collated comprehensive records of various toxicities caused by overdosing on NSAIDs. As result, we have presented a comprehensive overview of existing information on NSAIDs in this review. addition to that, we have concentrated on presenting our understanding of various organ-based toxicities caused due to NSAID's prolonged use/overdosage.

引用

页数：10