A Novel IMFET Biosensor Strategy for Interleukin-10 Quantification for Early Screening Heart Failure Disease in Saliva

被引：4

作者：

Ben Halima, Hamdi ^{[1
]}

Bellagambi, Francesca G. ^{[1
]}

Hangouet, Marie ^{[2
]}

Alcacer, Albert ^{[3
]}

Pfeiffer, Norman ^{[4
]}

Heuberger, Albert ^{[5
]}

Zine, Nadia ^{[1
]}

Bausells, Joan ^{[3
]}

Errachid, Abdelhamid ^{[1
]}

机构：

[1] Claude Bernard Lyon 1 Univ UCBL, Inst Analyt Sci ISA UMR 5280, F-69100 Lyon, France

[2] French Natl Ctr Sci Res CNRS, Inst Analyt Sci ISA UMR 5280, F-69100 Lyon, France

[3] CSIC, Inst Microelect Barcelona IMB CNM, Campus UAB, Barcelona 08193, Spain

[4] Fraunhofer Inst Integrated Circuits, Fraunhofer IIS, D-91058 Erlangen, Germany

[5] Friedrich Alexander Univ Erlangen Nurnberg FAU, Informat Technol LIKE, D-91058 Erlangen, Germany

来源：

ELECTROANALYSIS | 2023年 / 35卷 / 03期

基金：

欧盟地平线“2020”;

关键词：

IMFET; Interleukin-10; electrochemical impedance spectroscopy; Saliva analysis; Heart failure; TNF-ALPHA; IL-10; CYTOKINES;

D O I：

10.1002/elan.202200141

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

We propose a salivary Interleukin-10 detection strategy as part of an easily integrable Lab-on-Chip and Point-of-Care IMFET for multi-detection Heart Failure (HF) biomarkers. Our developed IMFET showed good linearity between increasing IL-10 concentration and the charge transfer resistance in both standard solutions and real saliva samples with a LOD of 0.02 pg mL(-1). Moreover, the cross-selectivity study showed that the developed IMFET was highly selective towards IL-10 against other HF biomarkers. The precision of our IMFET was also evaluated, and the difference between the determined IL-10 concentration using the standard addition method and its expected one is<20 %.

引用

页数：9

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