Uphill battle: Innovation of thiopurine therapy in global inflammatory bowel disease care

被引:8
作者
Bayoumy, Ahmed B. [1 ]
Mulder, Chris J. J. [2 ]
Ansari, Azhar R. [3 ]
Barclay, Murray L. [4 ,5 ]
Florin, Tim [6 ]
Kiszka-Kanowitz, Marianne [7 ]
Derijks, Luc [8 ,9 ]
Sharma, Vishal [10 ]
de Boer, Nanne K. H. [2 ]
机构
[1] Amsterdam Univ Med Ctr, Dept Internal Med, Amsterdam, Netherlands
[2] Vrije Univ Amsterdam, Amsterdam Univ Med Ctr, AGEM Res Inst, Dept Gastroenterol & Hepatol, Boelelaan 1117, NL-1081 HV Amsterdam, Netherlands
[3] London Bridge Hosp, Dept Gastroenterol & Hepatol, London, England
[4] Christchurch Hosp, Dept Gastroenterol, Christchurch, Waitaha Canterb, New Zealand
[5] Christchurch Hosp, Dept Clin Pharmacol, Christchurch, Waitaha Canterb, New Zealand
[6] Univ Queensland, Translat Res Inst, Mater Res, South Brisbane, Qld, Australia
[7] Amager & Hvidovre Hosp, Copenhagen Univ Hosp, Copenhagen Ctr Inflammatory Bowel Dis Children Ado, Hvidovre, Denmark
[8] Maxima Med Ctr, Dept Clin Pharm, Veldhoven, Netherlands
[9] Maastricht Univ, Med Ctr, Dept Clin Pharm & Toxicol, Maastricht, Netherlands
[10] Postgrad Inst Med Educ & Res, Dept Gastroenterol, Chandigarh 160012, India
关键词
Allopurinol; Azathioprine; Crohn's disease; Inflammatory bowel disease; Mercaptopurine; Thioguanine; Thiopurines; Ulcerative colitis; NODULAR REGENERATIVE HYPERPLASIA; COLITIS-ASSOCIATED CANCER; COLORECTAL NEOPLASIA; ULCERATIVE-COLITIS; INCREASED RISK; AZATHIOPRINE; PREVALENCE; CHALLENGES; LYMPHOMA; LIVER;
D O I
10.1007/s12664-024-01529-x
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the gastrointestinal tract that encompasses two major conditions: Crohn's disease (CD) and ulcerative colitis (UC). Historically, IBD has been primarily reported in western countries, but over the past decades, its prevalence is rapidly increasing, especially in lower and middle-income countries (LMICs) such as India and China and also in Sub-Saharan Africa. The prevalence of IBD in LMICs has been the subject of growing concern due to the impact of access to public healthcare and the burden it places on healthcare resources. The classical thiopurines face significant challenges due to cessation of therapy in approximately half of patients within one year due to side effects or ineffectiveness. In this article, we highlight innovating thiopurine treatment for IBD patients in downregulating side effects and improving efficacy.
引用
收藏
页码:36 / 47
页数:12
相关论文
共 86 条
[1]   Implications of the changing epidemiology of inflammatory bowel disease in a changing world [J].
Agrawal, Manasi ;
Jess, Tine .
UNITED EUROPEAN GASTROENTEROLOGY JOURNAL, 2022, 10 (10) :1113-1120
[2]  
[Anonymous], 2006, ALL
[3]  
[Anonymous], 2023, AV SAL IND
[4]   Long-term outcome of using allopurinol co-therapy as a strategy for overcoming thiopurine hepatotoxicity in treating inflammatory bowel disease [J].
Ansari, A. ;
Elliott, T. ;
Baburajan, B. ;
Mayhead, P. ;
O'Donohue, J. ;
Chocair, P. ;
Sanderson, J. ;
Duley, J. .
ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 2008, 28 (06) :734-741
[5]   Identifying Care Challenges as Opportunities for Research and Education in Inflammatory Bowel Disease in South Asia [J].
Balasubramaniam, Madhura ;
Nandi, Neilanjan ;
Aswani-Omprakash, Tina ;
Sebastian, Shaji ;
Sharma, Vishal ;
Deepak, Parakkal .
GASTROENTEROLOGY, 2022, 163 (05) :1145-1150
[6]   Managing inflammatory bowel disease: what to do when the best is unaffordable? [J].
Banerjee, Rupa ;
Raghunathan, Nalini ;
Pal, Partha .
LANCET GASTROENTEROLOGY & HEPATOLOGY, 2023, 8 (05) :396-398
[7]   Emerging inflammatory bowel disease demographics, phenotype, and treatment in South Asia, South-East Asia, and Middle East: Preliminary findings from the Inflammatory Bowel Disease-Emerging Nations' Consortium [J].
Banerjee, Rupa ;
Pal, Partha ;
Hilmi, Ida ;
Ghoshal, Uday C. ;
Desai, Devendra C. ;
Rahman, Mohammed Masudur ;
Dutta, Usha ;
Mohiuddin, Syed A. ;
Al Mohannadi, Munnera ;
Philip, Mathew ;
Ramesh, Ganesh N. ;
Niriella, Madunil A. ;
De Silva, Arjuna P. ;
de Silva, Hithanadura Janaka ;
Pisespongsa, Pises ;
Limsrivilai, Julajak ;
Aniwan, Satimai ;
Nawarathne, Metthananda ;
Fernandopulle, Nilesh ;
Aye, Than Than ;
Ni, Nwe ;
Al Awadhi, Sameer ;
Joshi, Neeraj ;
Ngoc, Pham Thi, V ;
Kieu, Tuan, V ;
Nguyen, Anh Duong ;
Abdullah, Murdani ;
Ali, Ezzat ;
Zeid, Ahmed ;
Sollano, Jose D. ;
Saberi, Bismillah ;
Omar, Mahmoud ;
Mohsin, Mostafa Noor ;
Aftab, Hafeza ;
Wai, Tin Moe ;
Shastri, Yogesh M. ;
Chaudhuri, Sujit ;
Ahmed, Faruque ;
Bhatia, Shobna J. ;
Travis, Simon P. L. .
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 2022, 37 (06) :1004-1015
[8]   NUDT15 C415T variant compared with TPMT genotyping in predicting azathioprine-induced leucopenia: prospective analysis of 1014 inflammatory bowel disease patients in India [J].
Banerjee, Rupa ;
Ravikanth, Vishnubhotla Venkata ;
Pal, Partha ;
Bale, Govardhan ;
Avanthi, Urmila Steffie ;
Goren, Idan ;
Girish, B. Ganesh ;
Mitnala, Sasikala ;
Reddy, D. Nageshwar .
ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 2020, 52 (11-12) :1683-1694
[9]   Proactive Metabolite Testing in Patients on Thiopurine May Yield Long-Term Clinical Benefits in Inflammatory Bowel Disease [J].
Barnes, Alex ;
Ooi, Soong-Yuan J. ;
Lynch, Kate D. ;
Parthasarathy, Nina ;
Bishara, Maria ;
Gounder, Michael ;
Grafton, Rachel ;
Leach, Peta ;
Bampton, Peter ;
Sechi, Alexandra ;
Ng, Watson ;
Connor, Susan ;
van Langenberg, Daniel ;
Mountifield, Reme ;
Andrews, Jane M. .
DIGESTIVE DISEASES AND SCIENCES, 2023, 68 (03) :889-896
[10]   Relationship Between Thiopurine S-Methyltransferase Genotype/Phenotype and 6-Thioguanine Nucleotide Levels in 316 Patients With Inflammatory Bowel Disease on 6-Thioguanine [J].
Bayoumy, Ahmed B. ;
Mulder, Chris J. J. ;
Loganayagam, Aathavan ;
Sanderson, Jeremy D. ;
Anderson, Simon ;
Boekema, Paul J. ;
Derijks, Luc J. J. ;
Ansari, Azhar R. .
THERAPEUTIC DRUG MONITORING, 2021, 43 (05) :617-623