Epigenetic mechanisms of particulate matter exposure: air pollution and hazards on human health

被引：10

作者：

Gavito-Covarrubias, Dulcemaria ^{[1
]}

Ramirez-Diaz, Ivonne ^{[1
,2
]}

Guzman-Linares, Josue ^{[1
]}

Limon, Ilhuicamina Daniel ^{[3
]}

Manuel-Sanchez, Dulce Maria ^{[3
]}

Molina-Herrera, Alejandro ^{[1
]}

Coral-Garcia, Miguel Angel ^{[1
]}

Anastasio, Estela ^{[1
]}

Anaya-Hernandez, Arely ^{[4
]}

Lopez-Salazar, Primavera ^{[5
]}

Juarez-Diaz, Gabriel ^{[5
]}

Martinez-Juarez, Javier ^{[5
]}

Torres-Jacome, Julian ^{[6
]}

Albarado-Ibanez, Alondra ^{[6
]}

Martinez-Laguna, Ygnacio ^{[7
]}

Moran, Carolina ^{[8
]}

Rubio, Karla ^{[1
]}

机构：

[1] Benemerita Univ Autonoma Puebla BUAP, Consejo Ciencia & Tecnol Estado Puebla CONCYTEP, Int Lab EPIGEN, Inst Ciencias, Puebla, Puebla, Mexico

[2] Univ Popular Autonoma Estado Puebla UPAEP, Puebla, Mexico

[3] Benemerita Univ Autonoma Puebla BUAP, Fac Chem Sci, Lab Neuropharmacol, Puebla, Mexico

[4] Univ Autonoma Tlaxcala, Ctr Invest Genet & Ambiente, Tlaxcala, Mexico

[5] Benemerita Univ Autonoma Puebla BUAP, Ctr Invest Disposit Semicond CIDS, Inst Ciencias, Puebla, Mexico

[6] Benemerita Univ Autonoma Puebla BUAP, Lab Fisiopatol Cardiovasc, Inst Ciencias, Puebla, Mexico

[7] Benemerita Univ Autonoma Puebla BUAP, Vicerrectoria Invest & Estudios Posgrad, Puebla, Mexico

[8] Benemerita Univ Autonoma Puebla BUAP, Ctr Invest Fisicoquim Mat, Inst Ciencias, Puebla, Mexico

来源：

FRONTIERS IN GENETICS | 2024年 / 14卷

关键词：

air pollution; epigenetic regulation; cancer; neurotoxicity; metabolism; fibrosis; oxidative stress; transgenerational epigenetics; DNA-REPAIR GENES; OXIDATIVE STRESS-RESPONSE; LONG-TERM EXPOSURE; PROMOTER METHYLATION; PM2.5; EXPOSURE; PRENATAL EXPOSURE; GLOBAL BURDEN; RISK-FACTOR; IN-VIVO; DISEASE;

D O I：

10.3389/fgene.2023.1306600

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Environmental pollution nowadays has not only a direct correlation with human health changes but a direct social impact. Epidemiological studies have evidenced the increased damage to human health on a daily basis because of damage to the ecological niche. Rapid urban growth and industrialized societies importantly compromise air quality, which can be assessed by a notable accumulation of air pollutants in both the gas and the particle phases. Of them, particulate matter (PM) represents a highly complex mixture of organic and inorganic compounds of the most variable size, composition, and origin. PM being one of the most complex environmental pollutants, its accumulation also varies in a temporal and spatial manner, which challenges current analytical techniques used to investigate PM interactions. Nevertheless, the characterization of the chemical composition of PM is a reliable indicator of the composition of the atmosphere, the quality of breathed air in urbanized societies, industrial zones and consequently gives support for pertinent measures to avoid serious health damage. Epigenomic damage is one of the most promising biological mechanisms of air pollution-derived carcinogenesis. Therefore, this review aims to highlight the implication of PM exposure in diverse molecular mechanisms driving human diseases by altered epigenetic regulation. The presented findings in the context of pan-organic cancer, fibrosis, neurodegeneration and metabolic diseases may provide valuable insights into the toxicity effects of PM components at the epigenomic level and may serve as biomarkers of early detection for novel targeted therapies.

引用

页数：23

共 260 条

[1] Lipid (per) oxidation in mitochondria: an emerging target in the ageing process? [J].