Risk of gastric adenoma and adenocarcinoma in patients with familial adenomatous polyposis in Japan: a nationwide multicenter study

被引：2

作者：

Sasaki, Kazuhito ^{[1
,2
]}

Kawai, Kazushige ^{[1
,3
]}

Nozawa, Hiroaki ^{[1
]}

Ishihara, Soichiro ^{[1
]}

Ishida, Hideyuki ^{[2
,4
]}

Ishibashi, Keiichiro ^{[4
]}

Mori, Yoshiko ^{[4
]}

Shichijo, Satoki ^{[2
,5
]}

Tani, Yasuhiro ^{[5
]}

Takeuchi, Yoji ^{[6
,7
]}

Chino, Akiko ^{[2
,8
]}

Takao, Misato ^{[3
]}

Fujiyoshi, Kenji ^{[2
,9
]}

Matsubara, Takaaki ^{[2
,10
]}

Miyakura, Yasuyuki ^{[2
,11
]}

Taniguchi, Fumitaka ^{[12
]}

Yamaguchi, Tatsuro ^{[2
,13
]}

Tanakaya, Kohji ^{[2
,12
]}

Tomita, Naohiro ^{[2
,14
]}

Ajioka, Yoichi ^{[2
,15
]}

机构：

[1] Univ Tokyo, Fac Med, Dept Surg Oncol, 7-3-1 Hongo,Bunkyo Ku, Tokyo 1138655, Japan

[2] Japanese Soc Canc Colon & Rectum, Comm Hereditary Colorectal Canc, Tokyo, Japan

[3] Tokyo Metropolitan Canc & Infect Dis Ctr Komagome, Dept Surg, Tokyo, Japan

[4] Saitama Med Univ, Saitama Med Ctr, Dept Digest Tract & Gen Surg, Saitama, Japan

[5] Osaka Int Canc Inst, Dept Gastrointestinal Oncol, Osaka, Japan

[6] Osaka Int Canc Inst, Dept Genet Oncol, Div Hereditary Tumors, Osaka, Japan

[7] Osaka Int Canc Inst, Dept Gastrointestinal Oncol, Osaka, Japan

[8] Canc Inst Hosp Japanese Fdn Canc Res, Dept Gastroenterol, Tokyo, Japan

[9] Kurume Univ, Sch Med, Dept Surg, Kurume, Japan

[10] Hyogo Coll Med, Dept Surg, Hyogo, Japan

[11] Jichi Med Univ, Saitama Med Ctr, Dept Surg, Saitama, Japan

[12] Natl Hosp Org Iwakuni Clin Ctr, Dept Surg, Yamaguchi, Japan

[13] Tokyo Metropolitan Canc & Infect Dis Ctr Komagome, Dept Clin Genet, Tokyo, Japan

[14] Toyonaka City Hosp, Dept Surg, Toyonaka, Japan

[15] Niigata Univ, Grad Sch Med & Dent Sci, Div Mol & Diagnost Pathol, Niigata, Japan

来源：

JOURNAL OF GASTROENTEROLOGY | 2024年 / 59卷 / 03期

关键词：

Familial adenomatous polyposis; Gastric adenoma; Gastric cancer; MUTATIONS; CANCER; IDENTIFICATION; APC; FAP; MORTALITY; TUMORS; GENES; COLI;

D O I：

10.1007/s00535-023-02074-8

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

BackgroundPatients with familial adenomatous polyposis (FAP) have an increased risk of developing gastric neoplasms. However, the clinical course of FAP with these gastric lesions has not yet been fully clarified. The present study aimed to clarify the changes in the incidence risk of developing gastric adenoma or gastric cancer during the lifespan of patients with FAP.MethodsFour hundred forty-three patients with data regarding gastric adenoma and gastric cancer retrospectively registered in a nationwide Japanese multicenter study were enrolled. The cumulative incidences and hazard rates (HRs) of gastric neoplasms were evaluated.ResultsThe cumulative incidence rates in 50-year-old patients with FAP were 22.8% for gastric adenoma and 7.6% for gastric cancer, respectively. No significant association was found between gastric neoplasms and the colonic phenotype. The peak age for the HR of gastric adenoma was 65 years, with the highest HR (0.043). Regarding the incidence of gastric cancer, the HR increased moderately up to the age of 40 years, but the increase accelerated from the age of 50 years (HR = 0.0067).ConclusionCareful surveillance of the upper gastrointestinal tract in elderly patients with FAP, such as shortening the interval of follow-up according to age, may be helpful for early diagnosis of gastric cancer.

引用

页码：187 / 194

页数：8

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