Current and future perspectives of single-cell multi-omics technologies in cardiovascular research

被引：3
作者：
Tan, Wilson Lek Wen [1 ]
Seow, Wei Qiang [1 ]
Zhang, Angela [1 ,2 ]
Rhee, Siyeon [1 ,2 ]
Wong, Wing H. [3 ,4 ]
Greenleaf, William J. [5 ]
Wu, Joseph C. [1 ,2 ,6 ]
机构：
[1] Stanford Cardiovasc Inst, Stanford, CA 94305 USA
[2] Greenstone Biosci, Palo Alto, CA 94304 USA
[3] Stanford Univ, Sch Med, Dept Stat, Stanford, CA USA
[4] Stanford Univ, Sch Med, Dept Biomed Data Sci, Stanford, CA USA
[5] Stanford Univ, Sch Med, Dept Genet, Stanford, CA USA
[6] Stanford Univ, Sch Med, Dept Med, Div Cardiovasc Med, Stanford, CA 94305 USA
来源：
NATURE CARDIOVASCULAR RESEARCH | 2023年 / 2卷 / 01期
基金：
美国国家卫生研究院;
关键词：
TRANSCRIPTOME ANALYSIS; GENE-EXPRESSION; RNA-SEQ; CHROMATIN ACCESSIBILITY; HUMAN HEART; REVEALS; PROTEINS; HETEROGENEITY; THOUSANDS; PLATFORM;
D O I：
10.1038/s44161-022-00205-7
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Single-cell technology has become an indispensable tool in cardiovascular research since its first introduction in 2009. Here, we highlight the recent remarkable progress in using single-cell technology to study transcriptomic and epigenetic heterogeneity in cardiac disease and development. We then introduce the key concepts in single-cell multi-omics modalities that apply to cardiovascular research. Lastly, we discuss some of the trending concepts in single-cell technology that are expected to propel cardiovascular research to the next phase of single-cell research. Wen Tan et al. review the current technologies available for single-cell transcriptomics, epigenomics and multi-omics analyses, their impact on the cardiovascular research and possible future applications.
引用
收藏
页码：20 / 34
页数：15
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