A Core Outcome Set for Interventions to Prevent and/or Treat Delirium in Palliative Care

被引:3
作者
Bryans, Anna [1 ]
Siddiqi, Najma [2 ,3 ]
Burry, Lisa [4 ,5 ]
Clarke, Mike [6 ]
Koffman, Jonathan [7 ]
Agar, Meera R. [8 ]
Rose, Louise [9 ,10 ]
机构
[1] Univ York, Dept Comp Sci, York, England
[2] Univ York, Hull York Med Sch, York, England
[3] Bradford Dist Care NHS Fdn Trust, Bradford, England
[4] Univ Toronto, Leslie Dan Fac Pharm, Toronto, ON, Canada
[5] Mt Sinai Hosp, Sinai Hlth Syst, Toronto, ON, Canada
[6] Queens Univ Belfast, Sch Med Dent & Biomed Sci, Belfast, North Ireland
[7] Univ Hull, Hull York Med Sch, Wolfson Palliat Care Res Ctr, Kingston Upon Hull, England
[8] Univ Technol Sydney, IMPACCT Ctr, Fac Hlth, Sydney, Australia
[9] Kings Coll London, Florence Nightingale Fac Nursing, Midwifery & Palliat Care, London, England
[10] Kings Coll London, Florence Nightingale Fac Nursing, Midwifery & Palliat Care, Rm 1-13,James Clerk Maxwell Bldg,57 Waterloo Rd, London SE1 8WA, England
基金
加拿大健康研究院;
关键词
Delirium; palliative care; core outcome set; clinical trials; END;
D O I
10.1016/j.jpainsymman.2023.05.013
中图分类号
R19 [保健组织与事业(卫生事业管理)];
学科分类号
摘要
Context. Delirium is a serious neurocognitive syndrome which is highly prevalent in people approaching the end of life. Existing trials of interventions to prevent or treat delirium in adults receiving palliative care report heterogeneous outcomes.Objectives. To undertake an international consensus process to develop a core outcome set for trials of interventions, designed to prevent and/or treat delirium, for adults receiving palliative care. Methods. The core outcome set development process included a systematic review, qualitative interviews, modified Delphi method and virtual consensus meetings using nominal group technique (Registration http://www.comet-initiative.org/studies/ details/796). Participants included family members, clinicians, and researchers with experience of delirium in palliative care.Results. Forty outcomes were generated from the systematic review and interviews informing the Delphi Round one survey. The international Delphi panel comprised 92 participants including clinicians (n = 71, 77%), researchers (n = 13, 14%), and family members (n = 8, 9%). Delphi Round two was completed by 77 (84%) participants from Round one. Following the consensus meetings, four outcomes were selected for the core outcome set: 1) delirium occurrence (incidence and prevalence); 2) duration of delirium until resolution defined as either no further delirium in this episode of care or death; 3) overall delirium symptom profile (agitation, delusions or hallucinations, delirium symptoms and delirium severity); 4) distress due to delirium (person with delirium, and/or family and/or carers [including healthcare professionals]). Conclusion. Using a rigorous consensus process, we developed a core outcome set comprising four delirium-specific out-comes for inclusion in future trials of interventions to prevent and/or treat delirium in palliative care.(c) 2023 The Authors. Published by Elsevier Inc. on behalf of American Academy of Hospice and Palliative Medicine. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
引用
收藏
页码:293 / +
页数:16
相关论文
共 31 条
[11]   Risk factors for delirium in adult patients receiving specialist palliative care: A systematic review and meta-analysis [J].
Featherstone, Imogen ;
Sheldon, Trevor ;
Johnson, Miriam ;
Woodhouse, Rebecca ;
Boland, Jason W. ;
Hosie, Annmarie ;
Lawlor, Peter ;
Russell, Gregor ;
Bush, Shirley ;
Siddiqi, Najma .
PALLIATIVE MEDICINE, 2022, 36 (02) :254-267
[12]   The experience of delirium in palliative care settings for patients, family, clinicians and volunteers: A qualitative systematic review and thematic synthesis [J].
Featherstone, Imogen ;
Hosie, Annmarie ;
Siddiqi, Najma ;
Grassau, Pamela ;
Bush, Shirley H. ;
Taylor, Johanna ;
Sheldon, Trevor ;
Johnson, Miriam J. .
PALLIATIVE MEDICINE, 2021, 35 (06) :988-1004
[13]   Drug therapy for delirium in terminally ill adults [J].
Finucane, Anne M. ;
Jones, Louise ;
Leurent, Baptiste ;
Sampson, Elizabeth L. ;
Stone, Patrick ;
Tookman, Adrian ;
Candy, Bridget .
COCHRANE DATABASE OF SYSTEMATIC REVIEWS, 2020, (01)
[14]   GRADE:: what is "quality of evidence" and why is it important to clinicians? [J].
Guyatt, Gordon H. ;
Oxman, Andrew D. ;
Vist, Gunn E. ;
Kunz, Regina ;
Falck-Ytter, Yngve ;
Schunemann, Holger .
BMJ-BRITISH MEDICAL JOURNAL, 2008, 336 (7651) :995-999B
[15]   Nominal group technique: An effective method for obtaining group consensus [J].
Harvey, Nichole ;
Holmes, Colin A. .
INTERNATIONAL JOURNAL OF NURSING PRACTICE, 2012, 18 (02) :188-194
[16]   Delirium prevalence, incidence, and implications for screening in specialist palliative care inpatient settings: A systematic review [J].
Hosie, Annmarie ;
Davidson, Patricia M. ;
Agar, Meera ;
Sanderson, Christine R. ;
Phillips, Jane .
PALLIATIVE MEDICINE, 2013, 27 (06) :486-498
[17]   Core Outcome Set-STAndards for Reporting: The COS-STAR Statement [J].
Kirkham, Jamie J. ;
Gorst, Sarah ;
Altman, Douglas G. ;
Blazeby, Jane M. ;
Clarke, Mike ;
Devane, Declan ;
Gorgon, Elizabeth ;
Moher, David ;
Schmitt, Jochen ;
Tugwell, Peter ;
Tunis, Sean ;
Williamson, Paula R. .
PLOS MEDICINE, 2016, 13 (10)
[18]   Core Outcome Measures for Palliative and End-of-Life Research After Severe Stroke Mixed-Method Delphi Study [J].
Mason, Bruce ;
Boyd, Kirsty ;
Doubal, Fergus ;
Barber, Mark ;
Brady, Marian ;
Cowey, Eileen ;
Visvanathan, Akila ;
Lewis, Steff ;
Gallacher, Katie ;
Morton, Sarah ;
Mead, Gillian E. .
STROKE, 2021, 52 (11) :3507-3513
[19]   Reversibility of delirium in Ill-hospitalized cancer patients: Does underlying etiology matter? [J].
Matsuda, Yoshinobu ;
Maeda, Isseki ;
Morita, Tatsuya ;
Yamauchi, Toshihiro ;
Sakashita, Akihiro ;
Watanabe, Hiroaki ;
Kaneishi, Keisuke ;
Amano, Koji ;
Iwase, Satoru ;
Ogawa, Asao ;
Yoshiuchi, Kazuhiro ;
Abo, Hirofumi ;
Akechi, Tatsuo ;
Akizuki, Nobuya ;
Okuyama, Tom ;
Fujisawa, Daisuke ;
Hagiwara, Shingo ;
Hirohashi, Takeshi ;
Hisanaga, Takayuki ;
Imai, Kengo ;
Inada, Shuji ;
Inoue, Satoshi ;
Inoue, Shinichiro ;
Iwata, Aio ;
Kumano, Akifumi ;
Matsui, Takashi ;
Matsumoto, Yoshihisa ;
Matsuo, Naoki ;
Miyajima, Kaya ;
Mori, Ichiro ;
Morita, Sachiyo ;
Nakahara, Rika ;
Nakajima, Nobuhisa ;
Nobata, Hiroyuki ;
Odagiri, Takuya ;
Shimizu, Ken ;
Watanabe, Yuki Sumazaki ;
Tagami, Keita ;
Takeuchi, Emi ;
Takeuchi, Mari ;
Tatara, Ryohei ;
Tokoro, Akihiro ;
Uchida, Megumi ;
Uemura, Keiichi ;
Yabuki, Ritsuko ;
Yokomichi, Naosuke .
CANCER MEDICINE, 2020, 9 (01) :19-26
[20]   A core outcome set for studies evaluating interventions to prevent and/or treat delirium for adults requiring an acute care hospital admission: an international key stakeholder informed consensus study [J].
Rose, Louise ;
Burry, Lisa ;
Agar, Meera ;
Blackwood, Bronagh ;
Campbell, Noll L. ;
Clarke, Mike ;
Devlin, John W. ;
Lee, Jacques ;
Marshall, John C. ;
Needham, Dale M. ;
Siddiqi, Najma ;
Page, Valerie .
BMC MEDICINE, 2021, 19 (01)