Invasive beta-haemolytic streptococcal infections, Finland, 2006 to 2020: increase in Lancefield group C/G infections

被引:3
|
作者
Paspaliari, Dafni Katerina [1 ,2 ]
Sarvikivil, Emmi [1 ]
Ollgrenl, Jukka [1 ]
Vuopio, Jaana [1 ,3 ,4 ]
机构
[1] Finnish Inst Hlth & Welf, Helsinki, Finland
[2] European Ctr Dis Prevent & Control ECDC, ECDC Fellowship Programme, Publ Hlth Microbiol path EUPHEM, Solna, Sweden
[3] Univ Turku, Inst Biomed, Turku, Finland
[4] Turku Univ Hosp, Clin Microbiol, Turku, Finland
关键词
DYSGALACTIAE SUBSP EQUISIMILIS; GROUP-A; GROUP-B; WESTERN NORWAY; GROUP-C; BACTEREMIA; DISEASE; EPIDEMIOLOGY; DENMARK;
D O I
10.2807/1560-7917.ES.2023.28.31.2200807
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
Background: Invasive infections with beta-haemolytic streptococci of Lancefield groups A (iGAS), B (iGBS) and C/G (iGCGS) are a major cause of morbidity and mortality worldwide. Aim: We studied incidence trends of invasive beta-haemolytic streptococcal infections in Finland, focusing on iGCGS. Methods: We conducted a retrospective register-based study. Cases were defined as isolations from blood and/or cerebrospinal fluid and retrieved from the National Infectious Disease Register where all invasive cases are mandatorily notified. Results: Between 2006 and 2020, the mean annual incidence was 4.1 per 100,000 for iGAS (range: 2.1-6.7), 5.2 for iGBS (4.0-6.3) and 10.1 for iGCGS (5.4-17.6). The incidence displayed an increasing trend for all groups, albeit for iGBS only for individuals 45 years and older. The increase was particularly sharp for iGCGS (8% annual relative increase). The incidence rate was higher in males for iGCGS (adjusted incidence rate ratio (IRR) = 1.6; 95% confidence interval (CI): 1.5-1.8) and iGAS (adjusted IRR = 1.3; 95% CI: 1.1-1.4); for iGBS, the association with sex was age-dependent. In adults, iGCGS incidence increased significantly with age. Recurrency was seen for iGCGS and secondarily iGBS, but not for iGAS. Infections with iGCGS and iGBS peaked in July and August. Conclusions: The incidence of invasive beta-haemolytic streptococcal infections in Finland has been rising since 2006, especially for iGCGS and among the elderly population. However, national surveillance still focuses on iGAS and iGBS, and European Union-wide surveillance is lacking. We recommend that surveillance of iGCGS be enhanced, including systematic collection and typing of isolates, to guide infection prevention strategies.
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页数:10
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