Laryngotracheal Resection After B-Raf Proto-oncogene Inhibition for Anaplastic Thyroid Carcinoma

被引：2
|
作者：
Kent, Johnathan [1 ]
Erwin, Philip
Haraf, Daniel
Liao, Chih-Yi
Durham, Joseph
Angelos, Peter
Agrawal, Nishant
Baird, Brandon Jackson
Madariaga, Maria Lucia L.
机构：
[1] Univ Chicago, Dept Gen Surg, 5841 S Maryland Ave, Chicago, IL 60637 USA
来源：
ANNALS OF THORACIC SURGERY | 2023年 / 115卷 / 05期
关键词：
D O I：
10.1016/j.athoracsur.2022.04.034
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Anaplastic thyroid carcinoma is a rare but aggressive neoplasm that often presents as advanced inoperable disease. Patients with B-Raf proto-oncogene (BRAF) v600e mutated anaplastic thyroid carcinoma who receive neoadjuvant dabrafenib/trametinib have improved rates of microscopically margin-negative resection and durable locoregional control. However this has not been evaluated in the setting of tracheal resection and primary reconstruction. Here we demonstrate the safety and efficacy of laryngotracheal resection and reconstruction after dabrafenib/trameti-nib for locoregionally advanced BRAF v600e mutated anaplastic thyroid carcinoma.
引用
收藏
页码：E117 / E120
页数：4
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