Polyphenolic Natural Products Active In Silico Against SARS-CoV-2 Spike Receptor Binding Domains and Non-structural Proteins-A Review

被引：15

作者：

Quimque, Mark Tristan ^{[1
,2
,3
]}

Notarte, Kin Israel ^{[4
]}

Adviento, Xela Amor ^{[5
]}

Cabunoc, Mikhail Harvey ^{[5
]}

de Leon, Von Novi ^{[6
]}

Reyes, Felippe Steven Louis delos ^{[7
]}

Lugtu, Eiron John ^{[5
]}

Manzano, Joe Anthony ^{[6
]}

Monton, Sofia Nicole ^{[5
]}

Munoz, John Emmanuel ^{[6
]}

Ong, Katherine Denise ^{[6
]}

Pilapil, Delfin Ynigo ^{[6
]}

Roque, Vito, III ^{[5
]}

Tan, Sophia Morgan ^{[6
]}

Lim, Justin Allen ^{[1
]}

Macabeo, Allan Patrick ^{[1
,8
]}

机构：

[1] Univ Santo Tomas, Res Ctr Nat & Appl Sci, Lab Organ React Discovery & Synth LORDS, Espana Blvd, Manila 1015, Philippines

[2] Univ Santo Tomas, Grad Sch, Espana Blvd, Manila 1015, Philippines

[3] Mindanao State Univ, Iligan Inst Technol, Coll Sci & Math, Dept Chem, Iligan 9200, Philippines

[4] Univ Santo Tomas, Fac Med & Surg, Espana Blvd, Manila 1015, Philippines

[5] Univ Santo Tomas, Fac Pharm, Dept Med Technol, Espana Blvd, Manila 1015, Philippines

[6] Univ Santo Tomas, Coll Sci, Dept Biol Sci, Espana Blvd, Manila 1015, Philippines

[7] Univ Philippines Baguio, Dept Biol, Governor Pack Rd, Baguio 2600, Philippines

[8] Univ Santo Tomas, Res Ctr Nat & Appl Sci, Lab Organ React Discovery & Synth LORDS, Manila, Philippines

来源：

COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING | 2023年 / 26卷 / 03期

关键词：

Polyphenols; COVID-19; SARS-CoV-2; molecular docking; flavonoids; Non-structural proteins; MOLECULAR DOCKING ANALYSIS; DEPENDENT RNA-POLYMERASE; DRIVEN DRUG DISCOVERY; MAIN PROTEASE; REGULATOR GRP78/BIP; MEDICINAL-PLANTS; TEA POLYPHENOLS; PRIME TARGETS; INFLUENZA-A; COVID-19;

D O I：

10.2174/1386207325666210917113207

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The ongoing Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) pandemic has been proven to be more severe than the previous coronavirus outbreaks due to the virus' high transmissibility. With the emergence of new variants, this global phenomenon took a more dramatic turn, with many countries recently experiencing higher surges of confirmed cases and deaths. On top of this, the inadequacy of effective treatment options for COVID-19 aggravated the problem. As a way to address the unavailability of target-specific viral therapeutics, computational strategies have been employed to hasten and systematize the search. The objective of this review is to provide initial data highlighting the utility of polyphenols as potential prophylaxis or treatment for COVID-19. In particular, presented here are virtually screened polyphenolic compounds which showed potential as either antagonists to viral entry and host cell recognition through binding with various receptor-binding regions of SARS-CoV-2 spike protein or as inhibitors of viral replication and post-translational modifications through binding with essential SARS-CoV-2 non-structural proteins.

引用

页码：459 / 488

页数：30

共 152 条

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