Is the anti-aging effect of ACE2 due to its role in the renin-angiotensin system?-Findings from a comparison of the aging phenotypes of ACE2-deficient, Tsukuba hypertensive, and Mas-deficient mice-

被引：7

作者：

Takeshita, Hikari ^{[1
,2
]}

Yamamoto, Koichi ^{[1
]}

Mogi, Masaki ^{[3
]}

Nozato, Satoko ^{[1
]}

Rakugi, Hiromi ^{[1
]}

机构：

[1] Osaka Univ, Grad Sch Med, Dept Geriatr & Gen Med, Osaka, Suita, Japan

[2] Morinomiya Univ Med Sci, Fac Med Sci Technol, Dept Med Sci Technol, Osaka, Osaka, Japan

[3] Ehime Univ, Grad Sch Med, Dept Pharmacol, Toon, Ehime, Japan

来源：

HYPERTENSION RESEARCH | 2023年 / 46卷 / 05期

关键词：

Renin-angiotensin system; ACE2; Aging; Sarcopenia; Skeletal muscle; SKELETAL-MUSCLE ATROPHY; TYPE-1 RECEPTOR BLOCKADE; CONVERTING ENZYME 2; DOUBLES LIFE-SPAN; BLOOD-PRESSURE; EXPRESSION; GROWTH; INHIBITION; APELIN; DEGRADATION;

D O I：

10.1038/s41440-023-01189-y

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

Angiotensin converting enzyme 2 (ACE2) functions as an enzyme that produces angiotensin 1-7 (A1-7) from angiotensin II (AII) in the renin-angiotensin system (RAS). We evaluated aging phenotypes, especially skeletal muscle aging, in ACE2 systemically deficient (ACE2 KO) mice and found that ACE2 has an antiaging function. The characteristic aging phenotype observed in ACE2 KO mice was not reproduced in mice deficient in the A1-7 receptor Mas or in Tsukuba hypertensive mice, a model of chronic AII overproduction, suggesting that ACE2 has a RAS-independent antiaging function. In this review, the results we have obtained and related studies on the aging regulatory mechanism mediated by RAS components will be presented and summarized.

引用

页码：1210 / 1220

页数：11

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