Is the anti-aging effect of ACE2 due to its role in the renin-angiotensin system?-Findings from a comparison of the aging phenotypes of ACE2-deficient, Tsukuba hypertensive, and Mas-deficient mice-

被引:6
作者
Takeshita, Hikari [1 ,2 ]
Yamamoto, Koichi [1 ]
Mogi, Masaki [3 ]
Nozato, Satoko [1 ]
Rakugi, Hiromi [1 ]
机构
[1] Osaka Univ, Grad Sch Med, Dept Geriatr & Gen Med, Osaka, Suita, Japan
[2] Morinomiya Univ Med Sci, Fac Med Sci Technol, Dept Med Sci Technol, Osaka, Osaka, Japan
[3] Ehime Univ, Grad Sch Med, Dept Pharmacol, Toon, Ehime, Japan
关键词
Renin-angiotensin system; ACE2; Aging; Sarcopenia; Skeletal muscle; SKELETAL-MUSCLE ATROPHY; TYPE-1 RECEPTOR BLOCKADE; CONVERTING ENZYME 2; DOUBLES LIFE-SPAN; BLOOD-PRESSURE; EXPRESSION; GROWTH; INHIBITION; APELIN; DEGRADATION;
D O I
10.1038/s41440-023-01189-y
中图分类号
R6 [外科学];
学科分类号
1002 ; 100210 ;
摘要
Angiotensin converting enzyme 2 (ACE2) functions as an enzyme that produces angiotensin 1-7 (A1-7) from angiotensin II (AII) in the renin-angiotensin system (RAS). We evaluated aging phenotypes, especially skeletal muscle aging, in ACE2 systemically deficient (ACE2 KO) mice and found that ACE2 has an antiaging function. The characteristic aging phenotype observed in ACE2 KO mice was not reproduced in mice deficient in the A1-7 receptor Mas or in Tsukuba hypertensive mice, a model of chronic AII overproduction, suggesting that ACE2 has a RAS-independent antiaging function. In this review, the results we have obtained and related studies on the aging regulatory mechanism mediated by RAS components will be presented and summarized.
引用
收藏
页码:1210 / 1220
页数:11
相关论文
共 86 条
  • [1] Protective Effect of Angiotensin 1-7 on Sarcopenia Induced by Chronic Liver Disease in Mice
    Aguirre, Francisco
    Abrigo, Johanna
    Gonzalez, Francisco
    Gonzalez, Andrea
    Simon, Felipe
    Cabello-Verrugio, Claudio
    [J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2020, 21 (11) : 1 - 16
  • [2] Angiotensin 1-7 prevents the excessive force loss resulting from 14-and 28-day denervation in mouse EDL and soleus muscle
    Albadrani, Hind
    Ammar, T.
    Bader, Michael
    Renaud, Jean-Marc
    [J]. JOURNAL OF GENERAL PHYSIOLOGY, 2021, 153 (12)
  • [3] Disruption of the Ang II type 1 receptor promotes longevity in mice
    Benigni, Ariela
    Corna, Daniela
    Zoja, Carla
    Sonzogni, Aurelio
    Latini, Roberto
    Salio, Monica
    Conti, Sara
    Rottoli, Daniela
    Longaretti, Lorena
    Cassis, Paola
    Morigi, Marina
    Coffman, Thomas M.
    Remuzzi, Giuseppe
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 2009, 119 (03) : 524 - 530
  • [4] Angiotensin II causes weight loss and decreases circulating insulin-like growth factor I in rats through a pressor-independent mechanism
    Brink, M
    Wellen, J
    Delafontaine, P
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 1996, 97 (11) : 2509 - 2516
  • [5] Angiotensin II induces skeletal muscle wasting through enhanced protein degradation and down-regulates autocrine insulin-like growth factor I
    Brink, M
    Price, SR
    Chrast, J
    Bailey, JL
    Anwar, A
    Mitch, WE
    Delafontaine, P
    [J]. ENDOCRINOLOGY, 2001, 142 (04) : 1489 - 1496
  • [6] The role of Pax genes in the development of tissues and organs:: Pax3 and Pax7 regulate muscle progenitor cell functions
    Buckingham, Margaret
    Relaix, Frederic
    [J]. ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, 2007, 23 : 645 - 673
  • [7] Skeletal muscle wasting: new role of nonclassical renin-angiotensin system
    Cabello-Verrugio, Claudio
    Rivera, Juan C.
    Garcia, Dominga
    [J]. CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE, 2017, 20 (03) : 158 - 163
  • [8] Renin-Angiotensin System: An Old Player with Novel Functions in Skeletal Muscle
    Cabello-Verrugio, Claudio
    Gabriela Morales, Maria
    Carlos Rivera, Juan
    Cabrera, Daniel
    Simon, Felipe
    [J]. MEDICINAL RESEARCH REVIEWS, 2015, 35 (03) : 437 - 463
  • [9] Tissue-Specific Amino Acid Transporter Partners ACE2 and Collectrin Differentially Interact With Hartnup Mutations
    Camargo, Simone M. R.
    Singer, Dustin
    Makrides, Victoria
    Huggel, Katja
    Pos, Klaas M.
    Wagner, Carsten A.
    Kuba, Keiji
    Danilczyk, Ursula
    Skovby, Flemming
    Kleta, Robert
    Penninger, Josef M.
    Verrey, Francois
    [J]. GASTROENTEROLOGY, 2009, 136 (03) : 872 - 882
  • [10] Angiotensin II, NADPH Oxidase, and Redox Signaling in the Vasculature
    Cat, Aurelie Nguyen Dinh
    Montezano, Augusto C.
    Burger, Dylan
    Touyz, Rhian M.
    [J]. ANTIOXIDANTS & REDOX SIGNALING, 2013, 19 (10) : 1110 - 1120